Journal of perinatology : official journal of the California Perinatal Association · 2026
Noninvasive oxygenation monitoring in PPHN: validation of the oxygen saturation index and the oxygen saturation to fraction of inspired oxygen ratio against conventional invasive indices.
СтатьяВалидационное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Li Dan, Yao Mulin, Shi Huixia, Jia Chao, Feng Lijuan, Ma Li, Tang Longmei
Аннотация
OBJECTIVE: To evaluate the correlation and agreement between the Oxygen Saturation Index (OSI) and Oxygenation Index (OI), and between the SpO2/FiO2 ratio (S/F) and PaO2/FiO2 ratio (P/F) in neonates with persistent pulmonary hypertension (PPHN), and to identify noninvasive thresholds for clinical use.
STUDY DESIGN: This retrospective study analyzed 2717 paired arterial blood gas and SpO2 measurements from 377 PPHN infants treated at a tertiary NICU (2012-2021). Correlation (Spearman), linear mixed-effects models (LMMs), Bland-Altman agreement, and ROC analyses were performed across SpO2 strata.
RESULTS: OSI strongly correlated with OI (r = 0.93), and S/F with P/F (r = 0.84), with best performance at SpO2 ≥80%. Agreement declined under severe hypoxemia. ROC analysis showed excellent discrimination for OSI (AUC > 0.96) and good performance for S/F (AUC up to 0.96).
CONCLUSION: OSI and S/F are reliable noninvasive surrogates for invasive oxygenation indices when SpO2 ≥ 80% and may help reduce arterial sampling in PPHN monitoring.
STUDY DESIGN: This retrospective study analyzed 2717 paired arterial blood gas and SpO2 measurements from 377 PPHN infants treated at a tertiary NICU (2012-2021). Correlation (Spearman), linear mixed-effects models (LMMs), Bland-Altman agreement, and ROC analyses were performed across SpO2 strata.
RESULTS: OSI strongly correlated with OI (r = 0.93), and S/F with P/F (r = 0.84), with best performance at SpO2 ≥80%. Agreement declined under severe hypoxemia. ROC analysis showed excellent discrimination for OSI (AUC > 0.96) and good performance for S/F (AUC up to 0.96).
CONCLUSION: OSI and S/F are reliable noninvasive surrogates for invasive oxygenation indices when SpO2 ≥ 80% and may help reduce arterial sampling in PPHN monitoring.