Retinal cases & brief reports · 2026
Bilateral Retinal Detachment after prophylactic laser therapy in Knobloch Syndrome.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
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Silva Caio A, Frasson Maria, Lima Joziele S, Nunes Brunelle F, Nehemy Márcio B
Аннотация
PURPOSE: Knobloch Syndrome (COL18A1-related) is a rare inherited vitreoretinopathy characterized by early-onset high myopia, regmatogenous retinal detachment and occipital skull and cutaneous defects. Although prophylactic retinal procedures have been proposed for related vitreoretinopathies, data supporting their use in Knobloch syndrome is scarce.
METHODS: Case Report.
RESULTS: An 8-year-old girl with genetically confirmed Knobloch syndrome who developed bilateral rhegmatogenous retinal detachment seven days after prophylactic laser therapy performed in a single-session bilaterally. Ultrawide-field retinography revealed bilateral inferotemporal retinal detachment associated with peripheral punched-out lesions. The patient underwent prompt sequential scleral buckle surgery with cryopexy and subretinal fluid drainage as indicated. Both retinas were successfully reattached and visual acuity returned to baseline values in the early postoperative period.
CONCLUSION: This case highlights limited evidence supporting laser prophylaxis in Knobloch syndrome and the importance of cautious, individualized decision-making as well as the need for further research to recommend for or against prophylaxis in this syndrome.
METHODS: Case Report.
RESULTS: An 8-year-old girl with genetically confirmed Knobloch syndrome who developed bilateral rhegmatogenous retinal detachment seven days after prophylactic laser therapy performed in a single-session bilaterally. Ultrawide-field retinography revealed bilateral inferotemporal retinal detachment associated with peripheral punched-out lesions. The patient underwent prompt sequential scleral buckle surgery with cryopexy and subretinal fluid drainage as indicated. Both retinas were successfully reattached and visual acuity returned to baseline values in the early postoperative period.
CONCLUSION: This case highlights limited evidence supporting laser prophylaxis in Knobloch syndrome and the importance of cautious, individualized decision-making as well as the need for further research to recommend for or against prophylaxis in this syndrome.