Inflammatory bowel diseases · 2026
Endoscopic and histologic healing distribution and persistent rectosigmoiditis in moderate-to-severe ulcerative colitis.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Ma Christopher, Hanzel Jurij, Sedano Rocio, Laroux F Stephen, Novak Gregor, Bressler Brian, Dong Hannah, Zou Guangyong, McFarlane Stefanie C, Bernstein Charles N, Narula Neeraj, Pai Rish K, Schaeffer David F, Panaccione Remo, Sands Bruce E, Feagan Brian G, Jairath Vipul
Аннотация
BACKGROUND: Mucosal healing in ulcerative colitis (UC) is believed to follow a proximal-to-distal pattern. We evaluated colonic healing distribution in patients with moderate-to-severe UC receiving adalimumab.
METHODS: Patients from the SERENE UC (Study of a Novel Approach to Induction and Maintenance Dosing with Adalimumab in Patients with Moderate to Severe Ulcerative Colitis) trial with full colonoscopies and segmental biopsies at screening, weeks 8, and 52 were included for endoscopic and histologic analyses if baseline Mayo endoscopic subscore (MES) or Robarts Histopathology Index (RHI) score, respectively, was >0 in the ascending, transverse, and/or descending colon. Data were analyzed using a mixed model for repeated measures to account for clustering of segments within a patient.
RESULTS: Endoscopic and histologic analyses comprised 76 and 79 patients, respectively. Score reductions were significantly greater vs the rectum in the ascending (week 8: MES, mean -0.78 [95% confidence interval (CI), -1.03 to -0.52]; RHI, mean -4.70 [95% CI, -6.92 to -2.49]; week 52: MES, mean -0.63 [95% CI, -0.91 to -0.35]; RHI, mean -2.39 [95% CI, -4.64 to -0.15]), transverse (week 8: MES, mean -0.69 [95% CI, -0.94 to -0.43]; RHI, mean -3.57 [95% CI, -5.62 to -1.51]; week 52: MES, mean -0.64 [95% CI, -0.89 to -0.38]; RHI, mean -2.88 [95% CI, -4.99 to -0.77]), and descending colon (week 8: MES, mean -0.40 [95% CI, -0.67 to -0.13]; RHI, mean -2.55 [95% CI, -4.94 to -0.16]; week 52: MES, mean -0.52 [95% CI, -0.70 to -0.34]; RHI, mean -3.47 [95% CI, -5.37 to -1.56]). Endoscopic improvement/remission and histologic remission were significantly more likely in the ascending and transverse colon than the rectum.
CONCLUSIONS: Our findings demonstrate that endoscopic and histologic healing is more challenging in the rectum compared with proximal colonic segments.
METHODS: Patients from the SERENE UC (Study of a Novel Approach to Induction and Maintenance Dosing with Adalimumab in Patients with Moderate to Severe Ulcerative Colitis) trial with full colonoscopies and segmental biopsies at screening, weeks 8, and 52 were included for endoscopic and histologic analyses if baseline Mayo endoscopic subscore (MES) or Robarts Histopathology Index (RHI) score, respectively, was >0 in the ascending, transverse, and/or descending colon. Data were analyzed using a mixed model for repeated measures to account for clustering of segments within a patient.
RESULTS: Endoscopic and histologic analyses comprised 76 and 79 patients, respectively. Score reductions were significantly greater vs the rectum in the ascending (week 8: MES, mean -0.78 [95% confidence interval (CI), -1.03 to -0.52]; RHI, mean -4.70 [95% CI, -6.92 to -2.49]; week 52: MES, mean -0.63 [95% CI, -0.91 to -0.35]; RHI, mean -2.39 [95% CI, -4.64 to -0.15]), transverse (week 8: MES, mean -0.69 [95% CI, -0.94 to -0.43]; RHI, mean -3.57 [95% CI, -5.62 to -1.51]; week 52: MES, mean -0.64 [95% CI, -0.89 to -0.38]; RHI, mean -2.88 [95% CI, -4.99 to -0.77]), and descending colon (week 8: MES, mean -0.40 [95% CI, -0.67 to -0.13]; RHI, mean -2.55 [95% CI, -4.94 to -0.16]; week 52: MES, mean -0.52 [95% CI, -0.70 to -0.34]; RHI, mean -3.47 [95% CI, -5.37 to -1.56]). Endoscopic improvement/remission and histologic remission were significantly more likely in the ascending and transverse colon than the rectum.
CONCLUSIONS: Our findings demonstrate that endoscopic and histologic healing is more challenging in the rectum compared with proximal colonic segments.