Indian journal of medical microbiology · 2026
Inflammatory Biomarkers (IL-6, IL-10, IL-17, TNF-α) in TB patients attending a tertiary care hospital in Bhubaneswar, Odisha : a cross - sectional study.
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Hussain Tahziba, Dhir Sanjeeb, Pati Silpa, Israt Nasreen, Mohapatra Sai Pravin, Dash Gurudutta, Pati Sanghamitra
Аннотация
BACKGROUND: Tuberculosis exhibits a complicated immune-pathogenesis that involves pro-inflammatory cytokines which modulate the host's immune responses. Cytokines like IL-6, IL-10, IL-17 and TNF-α are crucial in managing inflammation, immune protection and the progression of the disease that affect diagnostic and treatment responses.
AIM: In this study, the levels of cytokines IL-6, IL-10, IL-17 and TNF-α in the serum samples of pulmonary TB patients were estimated and their diagnostic significance was assessed and correlated with socio-demographic profile.
METHODS: Sera samples were collected from pulmonary TB patients attending a government hospital in Bhubaneswar, Odisha. Levels of IL-6, IL-10, IL-17 and TNF-α were quantified using commercial ELISA kits and cytokine concentrations were determined.
RESULTS: In this study, we found the levels of IL-6, IL-10 and IL-17 to be significantly lower in the serum samples of TB positive patients as compared to the healthy controls. The majority of subjects had comparatively low TNF-α levels, while some had significantly higher quantities. IL-6, IL-10 and IL-17 concentrations were lesser in TB patients. This implies that during active TB infection, IL-6 may be downregulated. IL-10 expression may be useful as an immunological marker for diagnosis of disease and monitoring of immune status. Reduced IL-17 expression is a hallmark of active TB and could be a helpful biomarker for diagnosis.
CONCLUSION: The cytokine profiling shows that these changes could provide valuable insights into the host immune response, help in development of diagnostic biomarkers and personalized therapeutic approaches in management of TB.
AIM: In this study, the levels of cytokines IL-6, IL-10, IL-17 and TNF-α in the serum samples of pulmonary TB patients were estimated and their diagnostic significance was assessed and correlated with socio-demographic profile.
METHODS: Sera samples were collected from pulmonary TB patients attending a government hospital in Bhubaneswar, Odisha. Levels of IL-6, IL-10, IL-17 and TNF-α were quantified using commercial ELISA kits and cytokine concentrations were determined.
RESULTS: In this study, we found the levels of IL-6, IL-10 and IL-17 to be significantly lower in the serum samples of TB positive patients as compared to the healthy controls. The majority of subjects had comparatively low TNF-α levels, while some had significantly higher quantities. IL-6, IL-10 and IL-17 concentrations were lesser in TB patients. This implies that during active TB infection, IL-6 may be downregulated. IL-10 expression may be useful as an immunological marker for diagnosis of disease and monitoring of immune status. Reduced IL-17 expression is a hallmark of active TB and could be a helpful biomarker for diagnosis.
CONCLUSION: The cytokine profiling shows that these changes could provide valuable insights into the host immune response, help in development of diagnostic biomarkers and personalized therapeutic approaches in management of TB.