Acta oto-laryngologica · 2026
Pre- and post-induction probiotic administration in experimental otitis media with effusion: effects on effusion resolution and inflammation.
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Ozdemir Coşkun, Celik Hatice, Kargin Kaytez Selda, Yumusak Nihat, Ercelik Onur, Arslan Necmi
Аннотация
BACKGROUND: Otitis media with effusion (OME) is a common inflammatory middle ear disease, and the efficacy of available medical treatments remains controversial. Probiotics have emerged as a potential non-antibiotic therapeutic strategy.
AIMS/OBJECTIVES: To compare the efficacy of methylprednisolone, montelukast, and Lactobacillus reuteri (L. reuteri) in the treatment of experimentally induced OME model.
MATERIAL AND METHODS: Thirty-five male Wistar albino rats were randomly assigned to five groups (n = 7). OME was induced by intratympanic histamine injection. Groups comprised control, methylprednisolone, montelukast, post-induction probiotics, and pre- and post-induction probiotics. Effusion resolution was assessed otomicroscopically, and submucosal inflammatory leukocyte infiltration was evaluated histologically.
RESULTS: Effusion resolution differed significantly among groups (p < 0.001), reaching 78.6% with methylprednisolone and 85.7% with pre- and post-induction probiotics, compared with 0% in controls. All treatment groups showed significantly lower submucosal inflammatory leukocyte counts than controls (p < 0.001). No statistically significant difference in inflammatory leukocyte counts was detected between the combined pre- and post-induction probiotic group and the methylprednisolone group in this exploratory study.
CONCLUSIONS AND SIGNIFICANCE: L. reuteri exhibited anti-inflammatory activity in this histamine-induced OME model. Combined pre- and post-induction probiotic administration was associated with greater effusion resolution than post-induction treatment alone, although longer total exposure may have contributed to this finding. These findings support further investigation of probiotics in OME but do not establish equivalent efficacy to methylprednisolone.
AIMS/OBJECTIVES: To compare the efficacy of methylprednisolone, montelukast, and Lactobacillus reuteri (L. reuteri) in the treatment of experimentally induced OME model.
MATERIAL AND METHODS: Thirty-five male Wistar albino rats were randomly assigned to five groups (n = 7). OME was induced by intratympanic histamine injection. Groups comprised control, methylprednisolone, montelukast, post-induction probiotics, and pre- and post-induction probiotics. Effusion resolution was assessed otomicroscopically, and submucosal inflammatory leukocyte infiltration was evaluated histologically.
RESULTS: Effusion resolution differed significantly among groups (p < 0.001), reaching 78.6% with methylprednisolone and 85.7% with pre- and post-induction probiotics, compared with 0% in controls. All treatment groups showed significantly lower submucosal inflammatory leukocyte counts than controls (p < 0.001). No statistically significant difference in inflammatory leukocyte counts was detected between the combined pre- and post-induction probiotic group and the methylprednisolone group in this exploratory study.
CONCLUSIONS AND SIGNIFICANCE: L. reuteri exhibited anti-inflammatory activity in this histamine-induced OME model. Combined pre- and post-induction probiotic administration was associated with greater effusion resolution than post-induction treatment alone, although longer total exposure may have contributed to this finding. These findings support further investigation of probiotics in OME but do not establish equivalent efficacy to methylprednisolone.