World neurosurgery · 2026
Time To Stable Programming After Staged vs Simultaneous Bilateral Subthalamic Deep Brain Stimulation Electrode Placement for Parkinson's Disease.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Yekuno Kalkidan, Marsans Maria, Drolett Cari, Roberts John, Srivastal Sindhu, Krause Katie, Bansal Aiyush, Farrokhi Farrokh
Аннотация
OBJECTIVE: To compare programming visits and time to stable stimulation and medication management after staged versus simultaneous bilateral subthalamic nucleus deep brain stimulation (DBS) for Parkinson's disease.
METHODS: This retrospective study included the original selected cohort of 10 staged and 10 simultaneous bilateral DBS patients, matched during cohort selection by age, disease duration, and surgical year. Continuous and count variables were summarized as medians and interquartile ranges (IQRs). Groups were compared using exact permutation Mann-Whitney tests and Fisher's exact test, as appropriate.
RESULTS: The simultaneous group required fewer programming visits than the staged group (median 3 [IQR 3-5] vs 7.5 [IQR 6-10], P < 0.001) and had a shorter interval from initial implantation to stable therapy (5.5 [IQR 3-7] vs 14.5 [IQR 12-17] months, P = 0.007). An exploratory comparison of recorded levodopa equivalent dose reduction did not detect a difference between groups (P = 0.905).
CONCLUSIONS: In this small retrospective cohort, simultaneous implantation was associated with fewer programming visits and a shorter overall interval to stable bilateral therapy. The timing difference includes the interval between staged procedures and does not establish superior clinical efficacy or equivalent medication outcomes.
METHODS: This retrospective study included the original selected cohort of 10 staged and 10 simultaneous bilateral DBS patients, matched during cohort selection by age, disease duration, and surgical year. Continuous and count variables were summarized as medians and interquartile ranges (IQRs). Groups were compared using exact permutation Mann-Whitney tests and Fisher's exact test, as appropriate.
RESULTS: The simultaneous group required fewer programming visits than the staged group (median 3 [IQR 3-5] vs 7.5 [IQR 6-10], P < 0.001) and had a shorter interval from initial implantation to stable therapy (5.5 [IQR 3-7] vs 14.5 [IQR 12-17] months, P = 0.007). An exploratory comparison of recorded levodopa equivalent dose reduction did not detect a difference between groups (P = 0.905).
CONCLUSIONS: In this small retrospective cohort, simultaneous implantation was associated with fewer programming visits and a shorter overall interval to stable bilateral therapy. The timing difference includes the interval between staged procedures and does not establish superior clinical efficacy or equivalent medication outcomes.