Parkinsonism & related disorders · 2026
An examination of the effect of dual task on gait in Parkinson's disease and REM sleep behavior disorder.
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Gallagher Catherine L, Haebig Maureen, Heroor Ananya, Tiwari Rachna, Plante David T, Okonkwo Ozioma C, Baker Jessica M, Buyan-Dent Laura, Mangin Teresa, Shannon Kathleen M, Pickett Kristen A
Аннотация
BACKGROUND: Gait variability is a hallmark of Parkinson's disease (PD) and has been linked to cognitive deficits and fall risk. Rapid eye movement sleep behavior disorder (RBD) is a strong predictor of synucleinopathies, yet evidence for gait changes in RBD is inconsistent. Performing a dual task increases gait variability, an effect that can be quantified using a cost function.
OBJECTIVE: Determine the degree to which dual task cost differs between control, RBD, and PD participants at baseline, and between RBD converters versus non-converters at follow-up.
METHODS: 46 RBD, 23 control, and 14 PD participants completed standardized gait analysis at baseline. Parameters chosen a priori for analysis included enhanced gait variability index (eGVI), functional ambulation performance (FAP), velocity, step length, cadence, base of support, and double support time. Medical records were surveilled for 3 years following participant enrollment, determining that 6 RBD participants converted to Parkinsonism. Baseline gait indices and dual task costs were compared between control, RBD, and PD groups at enrollment, and between RBD stable and RBD converters at follow-up.
RESULTS: The PD group had greater eGVI, as well as greater dual task cost for FAP, cadence, width, and double support time. No differences in gait variability or cost were identified between RBD and control groups at baseline. Compared to the stable group, RBD converters had greater dual task cost for FAP, velocity, cadence, and double support time.
CONCLUSIONS: Increases in dual task cost for specific gait parameters may identify RBD patients at imminent risk of phenoconversion.
OBJECTIVE: Determine the degree to which dual task cost differs between control, RBD, and PD participants at baseline, and between RBD converters versus non-converters at follow-up.
METHODS: 46 RBD, 23 control, and 14 PD participants completed standardized gait analysis at baseline. Parameters chosen a priori for analysis included enhanced gait variability index (eGVI), functional ambulation performance (FAP), velocity, step length, cadence, base of support, and double support time. Medical records were surveilled for 3 years following participant enrollment, determining that 6 RBD participants converted to Parkinsonism. Baseline gait indices and dual task costs were compared between control, RBD, and PD groups at enrollment, and between RBD stable and RBD converters at follow-up.
RESULTS: The PD group had greater eGVI, as well as greater dual task cost for FAP, cadence, width, and double support time. No differences in gait variability or cost were identified between RBD and control groups at baseline. Compared to the stable group, RBD converters had greater dual task cost for FAP, velocity, cadence, and double support time.
CONCLUSIONS: Increases in dual task cost for specific gait parameters may identify RBD patients at imminent risk of phenoconversion.