[Analysis of the patterns and characteristics of enhanced efficacy and reduced toxicity of acupuncture-medicine combination therapy].

Monotherapy often falls short in treating complex diseases effectively, prompting the emergence of integrated treatment models such as acupuncture-medicine combination therapy, which has gained recognition as a significant strategy to improve clinical efficacy while minimizing adverse effects. This paper systematically examines the necessity of integrating acupuncture with pharmacotherapy. By constructing a theoretical framework centered on supplementation and regulation, it delineates the operational principles of acupuncture-medicine combination therapy. It explores the mechanisms underlying the enhanced efficacy of acupuncture-medicine combination therapy from the perspectives of synergy and complementarity, and analyzes its characteristics in toxicity reduction via counteracting mechanisms. The aim of this paper is to provide a theoretical foundation and future directions for research on acupuncture-medicine combination therapy.