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Войти в исследования Resuscitation · 2026
Association Between Capnographic Changes During Pulse Checks of Varying Durations and Clinical Outcomes During Cardiopulmonary Resuscitation: A Multicenter Study From Türkiye (CaPTuRe).
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Yılmaz Gökhan, Özer Muhammet Raşit, Köylü Ramazan, Bora Ejder Saylav, Aksu Şakir Hakan, Arıkan Cüneyt, Çekmen Bora, Ataş İsmail, İnan Gülin, Arslan Müge, Bol Oğuzhan, Demir Ozan, Şahin Neslihan, Şahin Hüseyin, Erdoğan Arife, Demir Hüseyin Avni, Küçükceran Kadir, Ayrancı Mustafa Kürşat, Akıllı Nazire Belgin, Güler Ecem Ermete, Sönmez Bedriye Müge, Tarhan Alanur, Ersunan Gökhan, Bilir Özlem, Baykan Necmi, Toker İbrahim, Çelik Ahmet, Hür İzzettin, Gönüllü Hayriye, Bekfelavi Abdulhalik, Kadıoğlu Emine, Can Oğuzhan, Aktaş İsmail
Аннотация
AIM: To investigate the association between capnographic changes during pulse checks of different durations and cardiopulmonary resuscitation (CPR) outcomes.
METHODS: This multicenter, prospective, controlled, quasi-randomized study categorized patients according to pulse check duration: Group A (≤5 seconds) and Group B (>5 to ≤10 seconds). Five measurements were obtained during the first six CPR cycles. Four capnographic parameters were evaluated for each measurement: Post-CPR end-tidal carbon dioxide (ETCO2), Pre-CPR ETCO2, loss rate (percentage decrease between Post- and Pre-CPR ETCO2), and recovery time (time required to regain the previous cycle's Post-CPR ETCO2).
RESULTS: The study included 252 cardiac arrest patients (Group A, n=124; Group B, n=128). In Group A, patients with return of spontaneous circulation (ROSC) had markedly lower loss rates and shorter recovery times than non-survivors, together with higher pre- and post-CPR ETCO2 values (all p<0.001). Group A also had a higher ROSC rate than Group B (36.3% vs. 19.5%; p=0.005). Logistic regression identified pulse check duration as an independent predictor of ROSC, with Group A having 2.39-fold higher odds of ROSC than Group B (odds ratio [OR]=2.39, 95% confidence interval [CI]=1.347-4.242; p=0.003). Pre-CPR ETCO2 was strongly negatively correlated with loss rate (ρ=-0.770), whereas Pre- and Post-CPR ETCO2 values (ρ=0.96) and loss rate and recovery time (ρ=0.89) were strongly positively correlated.
CONCLUSION: Pulse checks completed within 5 seconds were associated with more favorable capnographic dynamics and higher ROSC rates than those lasting 6-10 seconds. These findings are hypothesis-generating and warrant prospective validation.
METHODS: This multicenter, prospective, controlled, quasi-randomized study categorized patients according to pulse check duration: Group A (≤5 seconds) and Group B (>5 to ≤10 seconds). Five measurements were obtained during the first six CPR cycles. Four capnographic parameters were evaluated for each measurement: Post-CPR end-tidal carbon dioxide (ETCO2), Pre-CPR ETCO2, loss rate (percentage decrease between Post- and Pre-CPR ETCO2), and recovery time (time required to regain the previous cycle's Post-CPR ETCO2).
RESULTS: The study included 252 cardiac arrest patients (Group A, n=124; Group B, n=128). In Group A, patients with return of spontaneous circulation (ROSC) had markedly lower loss rates and shorter recovery times than non-survivors, together with higher pre- and post-CPR ETCO2 values (all p<0.001). Group A also had a higher ROSC rate than Group B (36.3% vs. 19.5%; p=0.005). Logistic regression identified pulse check duration as an independent predictor of ROSC, with Group A having 2.39-fold higher odds of ROSC than Group B (odds ratio [OR]=2.39, 95% confidence interval [CI]=1.347-4.242; p=0.003). Pre-CPR ETCO2 was strongly negatively correlated with loss rate (ρ=-0.770), whereas Pre- and Post-CPR ETCO2 values (ρ=0.96) and loss rate and recovery time (ρ=0.89) were strongly positively correlated.
CONCLUSION: Pulse checks completed within 5 seconds were associated with more favorable capnographic dynamics and higher ROSC rates than those lasting 6-10 seconds. These findings are hypothesis-generating and warrant prospective validation.