Effect of vitamin D supplementation on fatigue and mood among perimenopausal women.

Perimenopausal women often experience fatigue and mood disturbances, which may be associated with vitamin D deficiency. Therefore, it is of interest to investigate the effect of vitamin D supplementation on fatigue and mood in perimenopausal women with vitamin D deficiency. A randomized, double-blind, placebo-controlled trial included 100 women who received either vitamin D3 or a placebo for 6 months. Results showed significant improvements in both fatigue and mood in the vitamin D group compared to placebo. Multivariate analysis confirmed vitamin D supplementation as a predictor of these improvements. Thus, vitamin D supplementation can effectively alleviate fatigue and improve mood in perimenopausal women with vitamin D deficiency.