Frontiers in immunology · 2026
Resistance-containing exercise versus non-exercise control for inflammatory markers and T-cell counts in adults living with HIV: a systematic review and meta-analysis.
СтатьяСистематический обзорМетаанализНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Zhang Jiayi, Gao Yafei, Zhang Zhentao, Lyu Zikun, Ma Jingshi
Аннотация
BACKGROUND: Adults living with HIV may have persistent immune activation and low-grade inflammation despite effective antiretroviral therapy. We assessed whether resistance training or resistance-containing combined exercise alters inflammatory biomarkers or T-cell counts versus non-exercise control.
METHODS: Six databases were searched to 1 June 2026 without language restrictions. Controlled intervention studies lasting at least four weeks were eligible. Screening and extraction were performed independently in duplicate. Inflammatory outcomes were expressed as Hedges' g; final-value SMDs were primary and change-score SMDs were analyzed separately, with one-trial strata reported individually. CD4+ T-cell count was pooled as a mean difference. Random-effects models used restricted maximum likelihood and Hartung-Knapp-Sidik-Jonkman intervals. RoB 2 or ROBINS-I and GRADE were applied.
RESULTS: Fifteen trials (18 reports) were included; 13 contributed quantitative data. All primary final-value confidence intervals included no effect: interleukin-6, -0.19 (95% CI -1.14 to 0.76; k = 4); tumor necrosis factor alpha, 0.07 (-1.44 to 1.57; k = 3); C-reactive protein, -0.02 (-1.46 to 1.41; k = 3); interleukin-1 beta, -0.47 (-10.09 to 9.15; k = 2); and interleukin-10, 0.04 (-11.37 to 11.46; k = 2). Interleukin-8 was reported by one final-value trial, -0.63 (-1.39 to 0.12), and was not pooled. Separate change-score analyses were also inconclusive except for one unpooled C-reactive protein trial. The pooled estimate for CD4+ T-cell count favored exercise by 124.2 cells/mm3 (54.6 to 193.7; k = 7), but the prediction interval crossed no effect. Certainty was very low.
CONCLUSION: The effects of resistance-containing exercise on inflammatory biomarkers remain undetermined. The CD4+ estimate suggests a possible increase, but confidence is very limited because the evidence is sparse, heterogeneous, at risk of bias, and its prediction interval includes no effect. Larger trials with well-defined comparators and complete contrast-form reporting are needed.
SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/view/CRD420261425700, identifier CRD420261425700.
METHODS: Six databases were searched to 1 June 2026 without language restrictions. Controlled intervention studies lasting at least four weeks were eligible. Screening and extraction were performed independently in duplicate. Inflammatory outcomes were expressed as Hedges' g; final-value SMDs were primary and change-score SMDs were analyzed separately, with one-trial strata reported individually. CD4+ T-cell count was pooled as a mean difference. Random-effects models used restricted maximum likelihood and Hartung-Knapp-Sidik-Jonkman intervals. RoB 2 or ROBINS-I and GRADE were applied.
RESULTS: Fifteen trials (18 reports) were included; 13 contributed quantitative data. All primary final-value confidence intervals included no effect: interleukin-6, -0.19 (95% CI -1.14 to 0.76; k = 4); tumor necrosis factor alpha, 0.07 (-1.44 to 1.57; k = 3); C-reactive protein, -0.02 (-1.46 to 1.41; k = 3); interleukin-1 beta, -0.47 (-10.09 to 9.15; k = 2); and interleukin-10, 0.04 (-11.37 to 11.46; k = 2). Interleukin-8 was reported by one final-value trial, -0.63 (-1.39 to 0.12), and was not pooled. Separate change-score analyses were also inconclusive except for one unpooled C-reactive protein trial. The pooled estimate for CD4+ T-cell count favored exercise by 124.2 cells/mm3 (54.6 to 193.7; k = 7), but the prediction interval crossed no effect. Certainty was very low.
CONCLUSION: The effects of resistance-containing exercise on inflammatory biomarkers remain undetermined. The CD4+ estimate suggests a possible increase, but confidence is very limited because the evidence is sparse, heterogeneous, at risk of bias, and its prediction interval includes no effect. Larger trials with well-defined comparators and complete contrast-form reporting are needed.
SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/view/CRD420261425700, identifier CRD420261425700.