Data-driven exploration of occupations and lung cancer risks using regularized regression models.
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Ge Calvin, Nie Jia, Portengen Lützen, Olsson Ann, Schüz Joachim, Ahrens Wolfgang, Barul Christine, Behrens Thomas, Brüning Thomas, Caporaso Neil E, Consonni Dario, Demers Paul A, Fabianova Eleonora, Fernández-Tardón Guillermo, Field John K, Forastiere Francesco, Foretova Lenka, Gustavsson Per, Janout Vladimir, Jöckel Karl-Heinz, Karrasch Stefan, Kendzia Benjamin, Kromhout Hans, Landi Maria Teresa, Lissowska Jolanta, Mates Dana, McLaughlin John R, Merletti Franco, Migliore Enrica, Pándics Tamás, Radoi Loredana, Richiardi Lorenzo, Schejbalova Miriam, Siemiatycki Jack, Świątkowska Beata, Wichmann Heinz-Erich, Zaridze David, Straif Kurt, Peters Susan, Vermeulen Roel
Аннотация
METHODS: We pooled data from 14 European and Canadian lung cancer case-control studies. The main analysis included 13 587 cases and 16 410 controls for men and 3199 cases and 4408 controls for women. Associations between ever-employment in various occupations and lung cancer risks were evaluated using two selection approaches: a least absolute shrinkage and selection operator regression and a two-stage Bayesian hierarchical horseshoe model accounting for age, study, smoking, and occupational exposure to known lung carcinogens. Unconditional logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for selected occupations.
RESULTS: For men, occupations consistently identified as positively associated with lung cancer included miners (OR = 1.28, 95% CI: 1.06-1.54) and bricklayers (OR = 1.30, 95% CI: 1.12-1.52), while secondary education teachers (OR = 0.37, 95% CI: 0.22-0.60), production managers (OR = 0.66, 95% CI: 0.54-0.81), and government executive officials (OR = 0.72, 95% CI: 0.62-0.83) were negatively associated. For women, secondary language and literature teachers (OR = 0.39, 95% CI: 0.20-0.72) and government executive officials (OR = 0.63, 95% CI: 0.48-0.81) showed negative associations.
CONCLUSION: Two agnostic, data-driven models identified several occupations associated with both increased and decreased lung cancer risks. These associations persisted after accounting for known exposures and covariates, highlighting the need to investigate unidentified occupational factors.