The trifecta of Plasmodium falciparum chromatin: open, closed, and centric.

Ramón-Zamorano et al. provide the first comprehensive characterization of protein complexes associated with heterochromatin, euchromatin, and centromeric chromatin in the malaria parasite Plasmodium falciparum. The study uncovers novel proteins involved in chromatin remodeling, sexual commitment, RNA-mediated regulation, and chromosome segregation, providing new insights into the chromatin-based mechanisms governing parasite development.