MedElevator
Войти в исследования Obesity (Silver Spring, Md.) · 2026
Obesity Increases Cardiovascular Strain During Passive Whole-Body Heat Stress in Middle-Aged Women.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Davila Georgia R, Fredericks Sandra N, Jennings William E, Haskell Emily A, Cooper Jamie A, Wolf S Tony
Аннотация
OBJECTIVE: Heat-related mortality is greater in middle-aged and older women, compared with age-matched men, and in those with obesity, although the causes are unclear.
METHODS: Thermoregulatory and cardiovascular responses were assessed in (n = 10 per group) young women (21 ± 2 years), middle-aged women without obesity (-OB; 55 ± 6 years), and middle-aged women with obesity (+OB; 55 ± 4 years) during whole-body heat stress until a change in core temperature (ΔTc) = 1°C. Cutaneous vasodilation (laser-Doppler flowmetry) and whole-body sweat rate (sweat loss/body surface area/time) were measured as indices of thermoregulatory function. Heart rate and blood pressure were measured, and rate pressure product (RPP = heart rate × systolic blood pressure) was calculated as an index of cardiovascular strain.
RESULTS: The magnitude of the peak cutaneous vasodilation response was not different among the groups (p ≥ 0.21), but thermosensitivity was higher in Young compared with +OB and -OB (p ≤ 0.03). Although there were no baseline differences in RPP (p ≥ 0.67), end-heating RPP was higher in +OB compared with -OB and Young (p ≤ 0.008). Further, body fat percentage was related to peak RPP (p = 0.03, R2 = 0.24) in middle-aged women.
CONCLUSIONS: Increased adiposity may contribute to greater cardiovascular risk during extreme heat exposure in middle-aged women.
METHODS: Thermoregulatory and cardiovascular responses were assessed in (n = 10 per group) young women (21 ± 2 years), middle-aged women without obesity (-OB; 55 ± 6 years), and middle-aged women with obesity (+OB; 55 ± 4 years) during whole-body heat stress until a change in core temperature (ΔTc) = 1°C. Cutaneous vasodilation (laser-Doppler flowmetry) and whole-body sweat rate (sweat loss/body surface area/time) were measured as indices of thermoregulatory function. Heart rate and blood pressure were measured, and rate pressure product (RPP = heart rate × systolic blood pressure) was calculated as an index of cardiovascular strain.
RESULTS: The magnitude of the peak cutaneous vasodilation response was not different among the groups (p ≥ 0.21), but thermosensitivity was higher in Young compared with +OB and -OB (p ≤ 0.03). Although there were no baseline differences in RPP (p ≥ 0.67), end-heating RPP was higher in +OB compared with -OB and Young (p ≤ 0.008). Further, body fat percentage was related to peak RPP (p = 0.03, R2 = 0.24) in middle-aged women.
CONCLUSIONS: Increased adiposity may contribute to greater cardiovascular risk during extreme heat exposure in middle-aged women.