Медицинская библиотека · Annals of neurology · 2026

Non-contrast CT Markers of Hematoma Expansion and Andexanet Response in Factor Xa Inhibitor-Associated Intracerebral Hemorrhage: An Analysis from ANNEXa-I Trial.

Tanaka Koji, Pensato Umberto, Alshamrani Mohamed, Katsanos Aristeidis H, Balali Pargol, Ray Sucharita, Kasner Scott E, Beyer-Westendorf Jan, Toni Danilo, Seiffge David J, Molina Carlos, Tanne David, Członkowska Anna, Lindgren Arne G, Bereczki Daniel, Sandset Else C, Tsivgoulis Georgios, Christensen Hanne, Coutinho Jonathan M, Verhamme Peter, Amarenco Pierre, Lemmens Robin, Veltkamp Roland, Middeldorp Saskia, Robinson Thompson, Milling Truman J, Lang Wilfried, Tedium-Cruz Vitor, Crowther Mark, Xu Lizhen, Knutsson Mikael, Ladenvall Per, Eikelboom John W, Sharma Mukul, Shoamanesh Ashkan, Demchuk Andrew M

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Аннотация

In this post hoc analysis of the ANNEXa-I trial (n = 434), we evaluated non-contrast computed tomography (NCCT) markers of hematoma expansion (HE) in factor Xa inhibitor (FXai) -associated intracerebral hemorrhage (ICH). At least one NCCT marker was present in 72.1%, and HE (≥12.5 mL or ≥ 35% increase in hematoma volume) occurred in 31.8%. Heterogeneous density, hypodensity, and the black hole sign were independently associated with HE. The effect of andexanet on HE was generally consistent across NCCT marker subgroups. These findings support the utility of NCCT markers for identifying patients at high risk of HE in FXai-associated ICH. ANN NEUROL 2026;100:979-983.

Для цитирования: Tanaka Koji, Pensato Umberto, Alshamrani Mohamed, Katsanos Aristeidis H, Balali Pargol, Ray Sucharita, Kasner Scott E, Beyer-Westendorf Jan, Toni Danilo, Seiffge David J, Molina Carlos, Tanne David, Członkowska Anna, Lindgren Arne G, Bereczki Daniel, Sandset Else C, Tsivgoulis Georgios, Christensen Hanne, Coutinho Jonathan M, Verhamme Peter, Amarenco Pierre, Lemmens Robin, Veltkamp Roland, Middeldorp Saskia, Robinson Thompson, Milling Truman J, Lang Wilfried, Tedium-Cruz Vitor, Crowther Mark, Xu Lizhen, Knutsson Mikael, Ladenvall Per, Eikelboom John W, Sharma Mukul, Shoamanesh Ashkan, Demchuk Andrew M. Non-contrast CT Markers of Hematoma Expansion and Andexanet Response in Factor Xa Inhibitor-Associated Intracerebral Hemorrhage: An Analysis from ANNEXa-I Trial.. Annals of neurology. 2026. DOI: 10.1002/ana.78347.

Предметные рубрики MeSH

Humans Cerebral Hemorrhage Factor Xa Inhibitors Male Tomography, X-Ray Computed Hematoma Female Aged Middle Aged Factor Xa Recombinant Proteins

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