Acta cirurgica brasileira · 2026
Electroacupuncture following microsurgical neurorrhaphy: functional and histological outcomes in a rat model.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Gonçalves Felipe Giraldo Alvarez, Chao Liaw Wen, Sampaio Emily Caroline da Fonseca, Domingos Neto Adriano Augusto, Abud Luiza Rafih, Hazan André Salo Buslik, Viterbo Fausto, Gemperli Rolf, Camargo Cristina Pires, Hsing Wu Tu
Аннотация
PURPOSE: This study evaluated electroacupuncture (EA) as adjunctive therapy after peripheral nerve repair in a rat model.
METHODS: Male Wistar rats underwent right sciatic nerve transection followed by neurorrhaphy and were randomized into EA or control groups. EA was performed twice weekly for 12 weeks. Sensory and motor recovery were assessed by nociceptive, mechanical, thermal, and sciatic functional index tests. Histological analyses evaluated Schwann cell and vascular densities, and gastrocnemius muscle weight was measured at euthanasia.
RESULTS: Sensory recovery was significantly greater in the EA group, with higher pain (3 [3-3.75] versus 2 [1-2], p = 0.02), pressure (2.5 [1.25-3] versus 0 [0-1], p = 0.009), and thermal sensitivity scores (2 [2-2.75] versus 0 [0-0], p = 0.02). Motor recovery and vascular density did not differ between groups. Distal Schwann cell density was significantly higher in the EA group (73.5 [67.4-74.1] versus 34.7 [34.5-38.4], p = 0.014). Gastrocnemius muscle weight was reduced in operated limbs in both groups, without intergroup differences.
CONCLUSION: EA improved sensory recovery and increased distal Schwann cell density, supporting its potential as an adjunctive therapy after peripheral nerve repair.
METHODS: Male Wistar rats underwent right sciatic nerve transection followed by neurorrhaphy and were randomized into EA or control groups. EA was performed twice weekly for 12 weeks. Sensory and motor recovery were assessed by nociceptive, mechanical, thermal, and sciatic functional index tests. Histological analyses evaluated Schwann cell and vascular densities, and gastrocnemius muscle weight was measured at euthanasia.
RESULTS: Sensory recovery was significantly greater in the EA group, with higher pain (3 [3-3.75] versus 2 [1-2], p = 0.02), pressure (2.5 [1.25-3] versus 0 [0-1], p = 0.009), and thermal sensitivity scores (2 [2-2.75] versus 0 [0-0], p = 0.02). Motor recovery and vascular density did not differ between groups. Distal Schwann cell density was significantly higher in the EA group (73.5 [67.4-74.1] versus 34.7 [34.5-38.4], p = 0.014). Gastrocnemius muscle weight was reduced in operated limbs in both groups, without intergroup differences.
CONCLUSION: EA improved sensory recovery and increased distal Schwann cell density, supporting its potential as an adjunctive therapy after peripheral nerve repair.