Liver transplantation as a treatment option for neuroendocrine liver metastases: a systematic review.

OBJETIVE: The aim was to carry out a systematic review of published articles on liver transplantation outcomes in patients with (LM-NET).

METHODS

We performed a systematic review according to the PRISMA guideline guidelines, using the MEDLINE (PubMed) and Scopus databases to identify published studies.

RESULTS

We included 2471 articles after the search, finally selecting 25. We collected data from 1005 patients, with a mean age of 47.9 years, most of them male. The most frequent locations of the primary tumor were the pancreas, followed by the small intestine. The disease-free survival was 25.3 months (14-31) and overall survival 38.5 months (32.5-57.1).

CONCLUSIONS

Liver transplantation appears to provide a survival benefit in patients with diffuse LM-NET without extrahepatic disease in selected cases.