Journal of Crohn's & colitis · 2026
Exploration of international differences in preoperative characteristics, indications, postoperative management and endoscopic recurrence rates in patients with Crohn's disease following ileocolic (re-)resection: first outcomes from the IMPACT consortium.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Bak Michiel T J, Hammoudi Nassim, Lee Sun-Ho, Maggiori Léon, van Ruler Oddeke, Bezault Madeleine, Hernandez-Rocha Cristian, de Vries Annemarie C, Silverberg Mark S, Allez Matthieu, IMPACT (International Multidisciplinary Research Collaboration on Postoperative IBD) consortium; on behalf of the Dutch Initiative on Crohn and Colitis and the RAP-CD study group; on behalf of the NIDDK Inflammatory Bowel Disease Genetics Consortium; on behalf of the REMIND study group
Аннотация
BACKGROUND: Reports on postoperative outcomes after ileocolic resection (ICR) in Crohn's disease (CD) vary widely. To provide insights into these differences, we compared international data on preoperative characteristics and postoperative management and outcome.
METHODS: CD patients undergoing ICR were included from prospective cohort studies in the Netherlands (NL), France (FR), Canada (CAN), and United States of America (USA).
RESULTS: Among 1761 patients, 79% underwent primary resection. In this population, surgery for Montreal classification B1 disease was more common (22% vs 0%-5%) and performed after shorter disease duration (4.3 vs 6.2-7.1 years) in NL than in other cohorts. Active smoking was more prevalent in NL and FR than in CAN and USA (23%-34% vs 7%-13%). In CAN, 54% were biologic-naive versus 27%-36% in other cohorts. Postoperative prophylaxis was prescribed in 28% of patients in NL and CAN, compared with 48% in FR and USA. Ileocolonoscopy within 12 months was performed in 72% in USA versus 88% in other cohorts. In the re-resection population, B1 disease at surgery and disease duration did not differ, whereas other findings were similar. Endoscopic postoperative recurrence (modified Rutgeerts' score ≥ i2b) varied from 36% in FR to 41% in NL, 15% in USA to 24% in CAN after primary resection and from 43% in NL, 46% in FR, 26% in CAN to 29% in USA cohort after re-resection.
CONCLUSIONS: Notable differences in preoperative characteristics and postoperative management and outcomes for ileocolic (re-)resections in CD were observed across European and North American countries.
METHODS: CD patients undergoing ICR were included from prospective cohort studies in the Netherlands (NL), France (FR), Canada (CAN), and United States of America (USA).
RESULTS: Among 1761 patients, 79% underwent primary resection. In this population, surgery for Montreal classification B1 disease was more common (22% vs 0%-5%) and performed after shorter disease duration (4.3 vs 6.2-7.1 years) in NL than in other cohorts. Active smoking was more prevalent in NL and FR than in CAN and USA (23%-34% vs 7%-13%). In CAN, 54% were biologic-naive versus 27%-36% in other cohorts. Postoperative prophylaxis was prescribed in 28% of patients in NL and CAN, compared with 48% in FR and USA. Ileocolonoscopy within 12 months was performed in 72% in USA versus 88% in other cohorts. In the re-resection population, B1 disease at surgery and disease duration did not differ, whereas other findings were similar. Endoscopic postoperative recurrence (modified Rutgeerts' score ≥ i2b) varied from 36% in FR to 41% in NL, 15% in USA to 24% in CAN after primary resection and from 43% in NL, 46% in FR, 26% in CAN to 29% in USA cohort after re-resection.
CONCLUSIONS: Notable differences in preoperative characteristics and postoperative management and outcomes for ileocolic (re-)resections in CD were observed across European and North American countries.