Abnormal resting-state EEG microstates correlate with objective sleep parameters in insomnia disorder.

BACKGROUND

Insomnia is a common sleep disorder, and Electroencephalogram (EEG) microstates, which mirror transient cerebral cortical functional activity, are linked to sleep disorder pathophysiology. The microstate characteristics in insomnia patients and correlations with objective sleep parameters remain to be further explored.

METHOD: This study enrolled 45 insomnia disorder (ID) patients and 48 healthy controls (HC), collecting awake resting-state EEG for microstate analysis; 27 ID and 13 H C participants additionally completed overnight polysomnography (PSG), and exploratory correlation analyses of microstate and PSG data performed for the ID group.

RESULTS

Compared with HC, ID patients had markedly shorter duration of microstate A and B, higher occurrence and contribution of microstate C, and reduced duration, occurrence and contribution of microstate D (p < 0.05). ID patients also showed significantly lower transition probabilities of A→D, B→D, D→A and D→B (p < 0.01), and higher probabilities of A→C, B→C, C→A and C→B (p < 0.05). Correlation analyses revealed that in the ID, microstate D occurrence was negatively correlated with rapid eye movement sleep proportion (REM Sleep%, r = -0.427, p = 0.026) and positively correlated with non-rapid eye movement sleep stage 1 proportion (S1%, r = 0.385, p = 0.047).

CONCLUSION

ID patients present significant abnormalities in EEG microstates, and the occurrence of microstate D is correlated with objective sleep indicators of PSG. These findings suggest that EEG microstate parameters may reflect abnormalities in the sleep architecture of ID and may provide references for analyzing the cortical hyperarousal mechanism of chronic insomnia, constructing objective assessment schemes, and developing targeted neuroregulation interventions.