Медицинская библиотека · Critical care medicine · 2026

Comparative Analysis of Tracheal Intubation-Associated Cardiac Arrest in 2015-2023: A Report From the National Emergency Airway Registry for Children Multicenter Registry.

Padiyath Asif, Padiyath Febina, Berg Robert A, Napolitano Natalie, Nadkarni Vinay, Shults Justine, Morales Knashawn H, Garcia-Marcinkiewicz Annery, Page-Goertz Christopher, Newman Jordan W, Harwayne-Gidansky Ilana, Ducharme-Crevier Laurence, Sanders Ronald C, Freeman Ashley D, Chiusolo Fabrizio, Breuer Ryan, Romer Amy, Glater Welt Lily B, Shenker Jennifer, Corbett Kelly L, Mallory Palen P, Mai Mark V, Polikoff Lee A, Krishna Ashwin S, Shenoi Asha, Loi Mervin V, Pinto Matthew, Bysani Gokul Kris, Lee Anthony, Gima Masafumi, Talukdar Andrea, McMahon Kimberly, Libertin Maria, Kelly Serena P, Krawiec Conrad, Branca Aline, Tellez David W, Levy Robert A, Nuthall Gabrielle A, Kovaleski Curtis, Piehl Mark, Al-Subu Awni M, Ahmed Aziez, Giuliano John S, Nishisaki Akira, National Emergency Airway Registry for Children (NEAR4KIDS) investigators as a subgroup of Pediatric Acute Lung Injury and Sepsis Investigators (PALISI)

СтатьяПеревод пока не подготовлен

Аннотация

OBJECTIVES

To determine the contemporary incidence of tracheal intubation-associated cardiac arrest (TI-CA) in critically ill children and identify potentially modifiable factors to prevent TI-CA in PICUs and pediatric cardiac ICUs (PCICUs).

DESIGN

Retrospective cohort study.

SETTING

Seventy international PICUs and PCICUs.

PATIENTS: Critically ill children requiring tracheal intubation in PICUs and PCICUs.

INTERVENTIONS: Tracheal intubation data were prospectively collected for all initial intubations in 68 PICUs and PCICUs from January 2015 to December 2023 using the National Emergency Airway Registry for Children registry.

MEASUREMENTS AND MAIN

RESULTS

TI-CA was defined as CA occurrence or receipt of chest compressions for at least 1 minute within 20 minutes of endotracheal tube placement. TI during ongoing cardiopulmonary resuscitation was not considered TI-CA. A total of 27,773 TIs were evaluated, with TI-CA reported in 1.2% (n = 331). Pre-TI oxygenation failure and shock were associated with higher odds of TI-CA (adjusted odds ratio [aOR], 2.29; 95% CI, 1.81-2.89 and aOR, 4.67; 95% CI, 3.68-5.92, respectively). Each additional TI attempt required was associated with increased odds of TI-CA (aOR, 1.70; 95% CI, 1.56-1.85, for each attempt). Use of ketamine (aOR, 0.64; 95% CI, 0.49-0.82), propofol (aOR, 0.44; 95% CI, 0.27-0.72), neuromuscular blockade (aOR, 0.67; 95% CI, 0.49-0.91), and video laryngoscopy (aOR, 0.76; 95% CI, 0.6-0.97) were associated with lower odds of TI-CA. Mediation analysis indicated that 13% of video laryngoscopy's protective effect was due to a reduction in TI attempt counts. The protective effects of ketamine, propofol, and neuromuscular blockade were minimally mediated by reduced TI attempt counts (5%, 4%, and 7%).

CONCLUSIONS

TI-CA occurred in 1.2% of TIs performed in the PICUs. Odds of TI-CA increased incrementally with successive TI attempts. Video laryngoscopy was protective against TI-CA. Mediation analysis revealed that reduced TI attempts accounted for 13% of the protective benefit associated with video laryngoscopy.

Для цитирования: Padiyath Asif, Padiyath Febina, Berg Robert A, Napolitano Natalie, Nadkarni Vinay, Shults Justine, Morales Knashawn H, Garcia-Marcinkiewicz Annery, Page-Goertz Christopher, Newman Jordan W, Harwayne-Gidansky Ilana, Ducharme-Crevier Laurence, Sanders Ronald C, Freeman Ashley D, Chiusolo Fabrizio, Breuer Ryan, Romer Amy, Glater Welt Lily B, Shenker Jennifer, Corbett Kelly L, Mallory Palen P, Mai Mark V, Polikoff Lee A, Krishna Ashwin S, Shenoi Asha, Loi Mervin V, Pinto Matthew, Bysani Gokul Kris, Lee Anthony, Gima Masafumi, Talukdar Andrea, McMahon Kimberly, Libertin Maria, Kelly Serena P, Krawiec Conrad, Branca Aline, Tellez David W, Levy Robert A, Nuthall Gabrielle A, Kovaleski Curtis, Piehl Mark, Al-Subu Awni M, Ahmed Aziez, Giuliano John S, Nishisaki Akira, National Emergency Airway Registry for Children (NEAR4KIDS) investigators as a subgroup of Pediatric Acute Lung Injury and Sepsis Investigators (PALISI). Comparative Analysis of Tracheal Intubation-Associated Cardiac Arrest in 2015-2023: A Report From the National Emergency Airway Registry for Children Multicenter Registry.. Critical care medicine. 2026. DOI: 10.1097/ccm.0000000000007390.

Подготовка и перевод публикации

Обработка статьи · этапы, ошибки и управление

Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.