Rapid Pain Reduction and Wound Closure Following Treatment With an Amorphous Silica-Based Fiber Wound Matrix in Partial-Thickness Thermal Burns: A Case Report.

Partial-thickness thermal burns can cause substantial pain and require effective wound management to support re-epithelialization. A 30-year-old man sustained 3%-4% total body surface area partial-thickness burns of the left hand, forearm, elbow, and abdomen following a gasoline-accelerated brush fire. Despite emergency debridement, dressings, and multimodal analgesia, pain remained 6-10/10. Approximately two days after injury, an amorphous silica-based fiber (SBF) wound matrix was applied to the open wounds, while a silica-based cream (SBC) was applied to surrounding intact skin. At initial SBF/SBC treatment, patient-reported pain decreased from 7/10 to 0/10 on a 0-10 numerical rating scale (NRS), with substantial relief reported within approximately 5-10 minutes. Across 12 paired assessments, mean pain decreased from 2.46/10 before treatment to 1.17/10 afterward. Serial planimetry demonstrated progressive wound closure with complete measured closure by Day 10, with sustained epithelial coverage and minimal scarring at Day 63. Because partial-thickness burns may spontaneously re-epithelialize, and this represents a single uncontrolled case with prior and concomitant treatment, causality cannot be established. The observed temporal pain response and wound-healing trajectory support prospective controlled evaluation using standardized pain, analgesic-use, epithelialization, functional, and safety endpoints.