Ophthalmic surgery, lasers & imaging retina · 2026
White and Dark Without Pressure Associated With Congenital Hypertrophy of the Retinal Pigment Epithelium.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Chadwick William F, Iddir Sabrina P, Ganesh Sanjay, Alahmadi Reem, Yao Xincheng, Heiferman Michael J
Аннотация
BACKGROUND AND OBJECTIVE: The purpose of this study was to evaluate the prevalence, spatial distribution, and multimodal imaging features of white without pressure (WWOP) and dark without pressure (DWOP) associated with congenital hypertrophy of the retinal pigment epithelium (CHRPE).
PATIENTS AND METHODS: This retrospective study included 101 patients (104 eyes; 106 lesions) with clinically diagnosed CHRPE evaluated between 2010 and 2025. Ultra-widefield fundus photography and optical coherence tomography (OCT) were reviewed for WWOP and DWOP prevalence, adjacency to CHRPE, and outer retinal changes.
RESULTS: WWOP was identified in 24 eyes (23%) and DWOP in 19 eyes (18%); four eyes (4%) exhibited both. WWOP was lesion-adjacent in 42% of cases, and DWOP was adjacent in 79% of cases. DWOP was associated with progressive ellipsoid-zone attenuation beyond the CHRPE margin on OCT. WWOP typically spanned a broader retinal area.
CONCLUSION: WWOP and DWOP are relatively common in CHRPE and demonstrate distinct spatial and OCT features. Multimodal imaging may aid differentiation of CHRPE from other pigmented lesions.
PATIENTS AND METHODS: This retrospective study included 101 patients (104 eyes; 106 lesions) with clinically diagnosed CHRPE evaluated between 2010 and 2025. Ultra-widefield fundus photography and optical coherence tomography (OCT) were reviewed for WWOP and DWOP prevalence, adjacency to CHRPE, and outer retinal changes.
RESULTS: WWOP was identified in 24 eyes (23%) and DWOP in 19 eyes (18%); four eyes (4%) exhibited both. WWOP was lesion-adjacent in 42% of cases, and DWOP was adjacent in 79% of cases. DWOP was associated with progressive ellipsoid-zone attenuation beyond the CHRPE margin on OCT. WWOP typically spanned a broader retinal area.
CONCLUSION: WWOP and DWOP are relatively common in CHRPE and demonstrate distinct spatial and OCT features. Multimodal imaging may aid differentiation of CHRPE from other pigmented lesions.