Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
Association between cognitive social capital and saliva-related quality of life among head and neck cancer survivors: a cross-sectional study.
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Darós Alan Carvalho, Knorst Jessica Klöckner, Emmanuelli Bruno, de Almeida Gonçalves João Alberto, Antoniazzi Raquel Pippi, Ferrazzo Kívia Linhares
Аннотация
PURPOSE: To evaluate the association between cognitive social capital and patient-reported saliva-related quality of life among head and neck cancer survivors.
METHODS: This cross-sectional study included adults treated with curative intent for squamous cell carcinoma of the lip/oral cavity, oropharynx, hypopharynx, or larynx at a referral hospital in southern Brazil. The outcome was patient-reported saliva-related quality of life, assessed using the saliva domain of the University of Washington Quality of Life questionnaire (UW-QOL); higher scores indicate better outcomes. Cognitive social capital was assessed using a brief three-item proxy index; participants were classified as scoring 3 (the maximum) or below 3. Hierarchical multiple linear regression estimated unstandardised coefficients (B) and 95% confidence intervals (95% CI), adjusting for education, tumour location, radiotherapy (yes vs. no), and time since treatment completion. Sensitivity analyses tested alternative operationalisations and adjustments.
RESULTS: A total of 105 adults participated (response rate 84.7%). The mean UW-QOL saliva-domain score was 61.85 ± 33.90, and 18 participants (17.1%) scored below 3. In the fully adjusted model, a score below 3 was associated with poorer saliva-related quality of life (B = -18.53; 95% CI -33.85 to -3.21; p = 0.018); sensitivity analyses were consistent.
CONCLUSION: In this exploratory study, lower scores on a three-item cognitive social capital proxy index were associated with poorer saliva-related quality of life among head and neck cancer survivors. Perceived social resources may be relevant to this burden, but these preliminary findings require confirmation in larger longitudinal studies.
METHODS: This cross-sectional study included adults treated with curative intent for squamous cell carcinoma of the lip/oral cavity, oropharynx, hypopharynx, or larynx at a referral hospital in southern Brazil. The outcome was patient-reported saliva-related quality of life, assessed using the saliva domain of the University of Washington Quality of Life questionnaire (UW-QOL); higher scores indicate better outcomes. Cognitive social capital was assessed using a brief three-item proxy index; participants were classified as scoring 3 (the maximum) or below 3. Hierarchical multiple linear regression estimated unstandardised coefficients (B) and 95% confidence intervals (95% CI), adjusting for education, tumour location, radiotherapy (yes vs. no), and time since treatment completion. Sensitivity analyses tested alternative operationalisations and adjustments.
RESULTS: A total of 105 adults participated (response rate 84.7%). The mean UW-QOL saliva-domain score was 61.85 ± 33.90, and 18 participants (17.1%) scored below 3. In the fully adjusted model, a score below 3 was associated with poorer saliva-related quality of life (B = -18.53; 95% CI -33.85 to -3.21; p = 0.018); sensitivity analyses were consistent.
CONCLUSION: In this exploratory study, lower scores on a three-item cognitive social capital proxy index were associated with poorer saliva-related quality of life among head and neck cancer survivors. Perceived social resources may be relevant to this burden, but these preliminary findings require confirmation in larger longitudinal studies.