Placenta · 2026
Associations of placental weight, placental weight-to-birthweight ratio, and in vivo markers of placental endocrine and metabolic function in humans.
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Kristiansen Oddrun, Henriksen Tore, Sajjad Muhammad U, Reine Trine M, Haugen Guttorm, Eskild Anne, Haavaldsen Camilla, Michelsen Trond M
Аннотация
PURPOSE: Placental weight and weight-to-birthweight ratio are widely used as indicators of placental function, yet their relationship with functional markers in humans remains unclear. This study explored the associations of placental weight and weight-to-birthweight ratio with indicators of placental endocrine function and metabolism and examined the associations between these indicators of placental endocrine function and metabolism.
METHODS: In this cross-sectional study, we included 116 healthy women undergoing planned cesarean delivery at term. Placental weight and birthweight were recorded. Endocrine and metabolic function were assessed using paired maternal and fetal blood samples combined with uteroplacental blood flow measurements (Doppler ultrasound, mL/min). Associations between the variables were examined by Spearman's correlation.
RESULTS: Placental weight and weight-to-birthweight ratio were not associated with the uteroplacental release of endocrine markers (placental growth factor, placental growth hormone, estradiol, or prolactin) into the maternal circulation (Spearman's rho, |ρ| = 0.02 - 0.17, p > 0.05), the uteroplacental uptake and consumption of glucose or ketones from the maternal circulation, or the uteroplacental release of lactate into the maternal circulation (|ρ| = 0.01 - 0.14, p > 0.05). Conversely, the uteroplacental release of endocrine markers to the maternal circulation was positively correlated with uteroplacental uptake and consumption of maternal glucose (|ρ| = 0.35 - 0.71, p = 0.012 - <0.001).
DISCUSSION: Placental weight did not appear to be closely related to its endocrine and metabolic function, suggesting limitations in its use as a proxy for functional capacity. However, the link between endocrine markers and glucose metabolism suggests shared regulatory pathways.
METHODS: In this cross-sectional study, we included 116 healthy women undergoing planned cesarean delivery at term. Placental weight and birthweight were recorded. Endocrine and metabolic function were assessed using paired maternal and fetal blood samples combined with uteroplacental blood flow measurements (Doppler ultrasound, mL/min). Associations between the variables were examined by Spearman's correlation.
RESULTS: Placental weight and weight-to-birthweight ratio were not associated with the uteroplacental release of endocrine markers (placental growth factor, placental growth hormone, estradiol, or prolactin) into the maternal circulation (Spearman's rho, |ρ| = 0.02 - 0.17, p > 0.05), the uteroplacental uptake and consumption of glucose or ketones from the maternal circulation, or the uteroplacental release of lactate into the maternal circulation (|ρ| = 0.01 - 0.14, p > 0.05). Conversely, the uteroplacental release of endocrine markers to the maternal circulation was positively correlated with uteroplacental uptake and consumption of maternal glucose (|ρ| = 0.35 - 0.71, p = 0.012 - <0.001).
DISCUSSION: Placental weight did not appear to be closely related to its endocrine and metabolic function, suggesting limitations in its use as a proxy for functional capacity. However, the link between endocrine markers and glucose metabolism suggests shared regulatory pathways.