Anti-Aging Efficacy of a Home-use red and Infrared Light-Emitting Diode Mask and a Cream: Ex Vivo and Clinical Evaluations in Women With Mature Skin.

BACKGROUND

Photobiomodulation has gained considerable attention for its potential in various dermatological applications. We assessed the anti-aging effects of a home-use face-fit mask combining 630 and 850 nm light-emitting diodes (LEDs) and an anti-aging cream in ex vivo and prospective exploratory clinical studies. Both products are commercially available.

METHODS

Skin samples from six women aged 39─55 years were either left untreated or received topical treatments for 7 days: LED irradiation (7-minute sessions) or cream (2 mg/cm2), or both. In the clinical study, women aged 49─65 years (n = 50) applied the cream daily to the face and neck for 56 days and used the mask 3─4 times per week.

RESULTS

Compared to untreated skin samples, the combination of LEDs and cream increased the expression of elastin (+29.6%) and collagen 1 (+7.6%) (p< 0.05 for both). The expression of elastin also increased following treatment with the LEDs alone (+26.1%; p< 0.05). the effect of LEDs and cream combined treatment was demonstrated on collagen 1 expression, with a similar trend observed for elastin expression. In the clinical study, investigator-assessed clinical scores showed significant progressive improvements from baseline, reaching +57.1% for skin radiance, -39.4% for pore dilatation, and -24.2% for crow's feet wrinkle depth at Day 56 (p< 0.0001 for all). Participants also perceived significantly improved skin radiance and smoothing of face and neck wrinkles throughout the study.

CONCLUSION

The LED mask and the anti-aging cream led to visible and clinically measurable skin signs of ageing reduction versus baseline. The increase in collagen I and elastin expression observed in the ex vivo study could contribute to the visible reduction in signs of aging demonstrated in the clinical study.