Neuroradiology · 2026
MR elastography and perfusion MRI characterize distinct biomechanical and vascular features of meningiomas.
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Fırat Zeynep, Ekinci Gazanfer, Türe Uğur
Аннотация
PURPOSE: To determine whether MR elastography (MRE) and dynamic susceptibility contrast (DSC) perfusion MRI provide overlapping or complementary information in meningiomas using anatomically matched regions of interest (ROIs).
METHODS: Fifty-five patients with histopathologically confirmed meningiomas who underwent preoperative 3-T MRE and DSC perfusion MRI were retrospectively analyzed. MRE-derived stiffness and relative cerebral blood volume (rCBV) were evaluated in whole-tumor, MRE-defined high-stiffness (local), and non-focal ROIs. Regional differences, histological subtype associations, stiffness-perfusion correlations, and the influence of calcification were assessed.
RESULTS: MRE-derived stiffness was higher in the local than non-focal ROI (p < 0.001), whereas rCBV did not differ significantly (p = 0.274). MRE-derived stiffness and rCBV were not significantly correlated in the local, whole-tumor, or non-focal ROIs (ρ = 0.085-0.182; all p ≥ 0.183). Fibroblastic meningiomas showed lower local rCBV than meningothelial meningiomas (median, 4.01 vs. 9.87; p = 0.004), whereas MRE-derived stiffness did not differ significantly among histological subtypes (local p = 0.748). In the fibroblastic-meningothelial comparison, the stiffness effect size was small with a confidence interval spanning zero (r = - 0.126; 95% bootstrap CI, - 0.51 to 0.29). SWI-detected calcification was associated with lower rCBV but not MRE-derived stiffness.
CONCLUSION: Perfusion did not differ significantly between MRE-defined high-stiffness and non-focal regions, and no significant stiffness-rCBV association was detected across ROI types. Perfusion MRI nevertheless demonstrated histological subtype-related differences not observed with MRE-derived stiffness, suggesting that the two modalities provide different, potentially complementary information about meningioma biomechanical and vascular features.
METHODS: Fifty-five patients with histopathologically confirmed meningiomas who underwent preoperative 3-T MRE and DSC perfusion MRI were retrospectively analyzed. MRE-derived stiffness and relative cerebral blood volume (rCBV) were evaluated in whole-tumor, MRE-defined high-stiffness (local), and non-focal ROIs. Regional differences, histological subtype associations, stiffness-perfusion correlations, and the influence of calcification were assessed.
RESULTS: MRE-derived stiffness was higher in the local than non-focal ROI (p < 0.001), whereas rCBV did not differ significantly (p = 0.274). MRE-derived stiffness and rCBV were not significantly correlated in the local, whole-tumor, or non-focal ROIs (ρ = 0.085-0.182; all p ≥ 0.183). Fibroblastic meningiomas showed lower local rCBV than meningothelial meningiomas (median, 4.01 vs. 9.87; p = 0.004), whereas MRE-derived stiffness did not differ significantly among histological subtypes (local p = 0.748). In the fibroblastic-meningothelial comparison, the stiffness effect size was small with a confidence interval spanning zero (r = - 0.126; 95% bootstrap CI, - 0.51 to 0.29). SWI-detected calcification was associated with lower rCBV but not MRE-derived stiffness.
CONCLUSION: Perfusion did not differ significantly between MRE-defined high-stiffness and non-focal regions, and no significant stiffness-rCBV association was detected across ROI types. Perfusion MRI nevertheless demonstrated histological subtype-related differences not observed with MRE-derived stiffness, suggesting that the two modalities provide different, potentially complementary information about meningioma biomechanical and vascular features.