Selectfluor-Mediated Radical Cyclization of N-Arylbicyclo[1.1.0]butane-1-carboxamides with Diaryldiselenides.

Herein, we report a Selectfluor-mediated radical cascade cyclization of bicyclo[1.1.0]butanes (BCBs) with diaryl selenides through strain-promoted C-C σ-bond cleavage. This protocol provides a facile and efficient approach to selenium-decorated 3-spirocyclobutyl oxindoles in up to 99% yield for 30 examples. Moreover, the reaction is readily scalable to the gram scale, demonstrating its practical applicability. This protocol features a broad scope of substrate, peroxide-free, rapid, mild, and environmentally benign conditions, with excellent tolerance of broad functional groups.