Cinnamaldehyde-g-hyaluronic-acid-coated nano-MOF for light-free photodynamic therapy through a chemiluminescence resonance energy transfer strategy.

A cinnamaldehyde-g-hyaluronic-acid-coated nano-MOF enables light-free photodynamic therapy via chemiluminescence resonance energy transfer. It promotes H2O2 generation in situ, facilitates O2 supply, and reduces porphyrin π-π stacking through the spatial confinement of the MOF framework, achieving potent antitumor efficacy without external light.