Photocatalytic C-H Trifluoromethylation of (Hetero)arenes with Halon-1301.

Bromotrifluoromethane (CF3Br, Halon-1301) is a potent greenhouse gas and ozone-depleting substance. Here, we report the use of CF3Br as a trifluoromethyl source for the photocatalytic C-H trifluoromethylation of (hetero)arenes. The reaction proceeds at ambient temperature and pressure without an external oxidant, affords products in yields of up to 89%, and accommodates bioactive molecules, including nucleosides, providing a route for the value-added utilization of Halon-1301.