Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2026
[Association of the rs1801260 T>C polymorphism of the CLOCK gene with sleep quality and buccal epithelial DNA damage in schoolchildren in the Arctic: A pilot study].
Аннотация на английскомСтатьяНазвание и аннотация: Оригинал на русском
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Kolomeichuk S N, Petrashova D A, Pozharskaya V V, Morozov A V, Gubin D G
Аннотация
OBJECTIVE: To assess the impact of the rs1801260 T>C polymorphism in the CLOCK gene and environmental light conditions on sleep quality and cytogenetic instability among children living at high latitudes.
MATERIAL AND METHODS: The study included 77 schoolchildren aged 15 to 17 years (mean age 15.4 years; 58.4% female). The rs1801260 polymorphism in the CLOCK gene was analyzed using buccal epithelial samples collected from healthy participants.
RESULTS: Individuals with the CC genotype at the rs1801260 polymorphism of the CLOCK gene exhibited a higher frequency of nuclear protrusions and reduced sleep quality compared to carriers of the T allele.
CONCLUSIONS: The rs1801260 polymorphism in the CLOCK gene may be associated with increased sensitivity to genotoxic environmental factors.
MATERIAL AND METHODS: The study included 77 schoolchildren aged 15 to 17 years (mean age 15.4 years; 58.4% female). The rs1801260 polymorphism in the CLOCK gene was analyzed using buccal epithelial samples collected from healthy participants.
RESULTS: Individuals with the CC genotype at the rs1801260 polymorphism of the CLOCK gene exhibited a higher frequency of nuclear protrusions and reduced sleep quality compared to carriers of the T allele.
CONCLUSIONS: The rs1801260 polymorphism in the CLOCK gene may be associated with increased sensitivity to genotoxic environmental factors.