Maturitas · 2026
Hysterectomy, bilateral oophorectomy, and risk of type 2 diabetes: Evidence from the E3N-generations cohort.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Hachem Sara, Vaduva Patricia, Laouali Nasser, Gelot Amandine, Briand Marine, Eon Solène, Kvaskoff Marina, Bonnet Fabrice
Аннотация
OBJECTIVES: Evidence on hysterectomy and the risk of type 2 diabetes is limited, particularly regarding age at surgery. We assessed whether hysterectomy, with or without bilateral oophorectomy, is associated with incident type 2 diabetes, and whether this association is modified by age at surgery.
STUDY DESIGN: We followed 82,472 women from the E3N-Generations cohort, free of diabetes at baseline in 1992, until 2008 (median follow-up 16 years). Hysterectomy and oophorectomy were modelled as time-dependent exposures. Hazard ratios were estimated using Cox models with age as the time scale, adjusted for lifestyle, metabolic, and reproductive factors.
MAIN OUTCOME MEASURE: Incidence of type 2 diabetes.
RESULTS: During follow-up, 2318 women developed type 2 diabetes. In fully adjusted models, hysterectomy combined with bilateral oophorectomy was associated with a higher risk of type 2 diabetes (hazard ratio 1.23, 95% confidence interval 1.07-1.43) compared with women who underwent neither procedure, whereas hysterectomy alone was not (1.06, 0.91-1.24). Bilateral oophorectomy alone was not associated with the risk of incident type 2 diabetes. The association with hysterectomy and bilateral oophorectomy was strongest among women operated on before age 45 (1.70, 1.35-2.15); it was similarly elevated when the age threshold was changed to 40 (1.54, 1.08-2.20). There was significant heterogeneity by age at surgery for hysterectomy with bilateral oophorectomy (p = 0.001) and for hysterectomy alone (p = 0.010).
CONCLUSIONS: Hysterectomy with bilateral oophorectomy was associated with an increased risk of incident type 2 diabetes, independently of conventional metabolic risk factors. This excess risk was particularly pronounced among women who underwent surgery before age 45.
STUDY DESIGN: We followed 82,472 women from the E3N-Generations cohort, free of diabetes at baseline in 1992, until 2008 (median follow-up 16 years). Hysterectomy and oophorectomy were modelled as time-dependent exposures. Hazard ratios were estimated using Cox models with age as the time scale, adjusted for lifestyle, metabolic, and reproductive factors.
MAIN OUTCOME MEASURE: Incidence of type 2 diabetes.
RESULTS: During follow-up, 2318 women developed type 2 diabetes. In fully adjusted models, hysterectomy combined with bilateral oophorectomy was associated with a higher risk of type 2 diabetes (hazard ratio 1.23, 95% confidence interval 1.07-1.43) compared with women who underwent neither procedure, whereas hysterectomy alone was not (1.06, 0.91-1.24). Bilateral oophorectomy alone was not associated with the risk of incident type 2 diabetes. The association with hysterectomy and bilateral oophorectomy was strongest among women operated on before age 45 (1.70, 1.35-2.15); it was similarly elevated when the age threshold was changed to 40 (1.54, 1.08-2.20). There was significant heterogeneity by age at surgery for hysterectomy with bilateral oophorectomy (p = 0.001) and for hysterectomy alone (p = 0.010).
CONCLUSIONS: Hysterectomy with bilateral oophorectomy was associated with an increased risk of incident type 2 diabetes, independently of conventional metabolic risk factors. This excess risk was particularly pronounced among women who underwent surgery before age 45.