Nickel-Catalyzed Enantioselective Synthesis of Chiral Alkenyl Sulfoxides.

The nickel-catalyzed asymmetric C(sp2)-S cross-coupling of in situ generated sulfenate anion with alkenyl bromides has been reported. This method addresses catalyst poisoning by sulfur reagents through in situ generation of sulfenate anion species in combination with diphosphine ligand modulation, thereby stabilizing the nickel catalyst. This protocol enables the highly efficient and enantioselective synthesis of structurally diverse alkenyl sulfoxides. In addition, this method provides a practical platform for the divergent synthesis of complex chiral sulfoxide architectures.