Movement disorders clinical practice · 2026
Cognitive, Motor and Oculomotor Contributions to the Trail Making Test in Progressive Supranuclear Palsy.
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Garcia-Cordero Indira, Hadian Mohsen, Vargas-Gonzalez Juan Camilo, Monteiro Marta, Gold David, Khoja Abeer, Morales-Rivero Alonso, Couto Blas, Tang-Wai David, Fox Susan, Kovacs Gabor G, Lang Anthony E, Tartaglia Maria Carmela
Аннотация
BACKGROUND: Progressive supranuclear palsy (PSP) is a neurodegenerative disorder characterized by motor, oculomotor and cognitive impairments. Yet disentangling cognitive deficits from motor and oculomotor dysfunction remains a diagnostic and methodological challenge.
OBJECTIVES: This study aims to evaluate how cognitive, motor, and oculomotor impairments contribute to performance in the Trail Making Test (TMT) in PSP patients.
METHODS: Eighty-one patients with PSP-Richardson's syndrome underwent the Toronto Cognitive Assessment, the Movement Disorder Society Unified Parkinson's Disease Rating Scale-part III and the PSP rating scale. Structural equation modeling was used to examine associations between TMT performance, cognitive function, and motor/oculomotor measures derived from these assessments.
RESULTS: TMT performance was mainly driven by cognitive factors, particularly executive function, with no significant influence from motor or oculomotor deficits.
CONCLUSIONS: These findings suggest that the TMT is a valuable tool for assessing cognitive impairment in PSP, reflecting fronto-striatal (associative loop) dysfunction rather than motor or oculomotor impairments.
OBJECTIVES: This study aims to evaluate how cognitive, motor, and oculomotor impairments contribute to performance in the Trail Making Test (TMT) in PSP patients.
METHODS: Eighty-one patients with PSP-Richardson's syndrome underwent the Toronto Cognitive Assessment, the Movement Disorder Society Unified Parkinson's Disease Rating Scale-part III and the PSP rating scale. Structural equation modeling was used to examine associations between TMT performance, cognitive function, and motor/oculomotor measures derived from these assessments.
RESULTS: TMT performance was mainly driven by cognitive factors, particularly executive function, with no significant influence from motor or oculomotor deficits.
CONCLUSIONS: These findings suggest that the TMT is a valuable tool for assessing cognitive impairment in PSP, reflecting fronto-striatal (associative loop) dysfunction rather than motor or oculomotor impairments.