The combination of 1064 nm pulsed Nd:YAG laser and ALA-PDT for Phymatous Rosacea.

Rosacea is a common chronic inflammatory disease. Among its four subtypes, phymatous rosacea predominantly affects middle-aged and elderly men and is characterized by hyperplasia and hypertrophy of both fibrous tissue and sebaceous glands of the nose. The visible manifestation is often considered a disfigurement and the accompanying social stigma may cause emotional and physical impact. In this article, we describe a combination therapy of a 1064 nm Nd:YAG laser (Sichuan Aerospace World Guidance Co., Ltd.; fiber core diameter: 0.6 mm; laser energy: 100-200 mJ) and ALA-PDT (20% 5-aminolevulinic acid: Fudan Zhangjiang Co., Ltd., Shanghai, China and red light: Sigma, 635 nm wavelength, 60-80 mW/cm² irradiation energy for 15-20 min). This combined regimen achieved satisfactory clinical outcomes with minimal adverse effects, including little bleeding and a low risk of postoperative infection. Furthermore, it facilitated convenient postoperative home care for the patient.