Ambient Light-Activatable Luminescent Particle-Embedded Conformal Patch for Photochemical Tissue Bonding and Photobiomodulated Healing.

Biophotonic healthcare devices have been widely investigated for photochemical tissue bonding (PTB), photobiomodulation (PBM), photodynamic therapy (PDT), and photothermal therapy (PTT). However, their clinical applications remain limited due to the short light penetration depth and the incompliant light source, including externally powered light-emitting diodes (LEDs). Here, we present a stretchable photonic patch embedded with biocompatible room light- and sunlight-activatable luminescent particles (RSLPs) in an elastomeric matrix. This patch enables ambient light-activatable phototherapy without an external light source by absorbing broadband ambient light and converting it into red luminescence. The emission promotes PTB, fibroblast proliferation, and M1/M2 macrophage polarization for tissue regeneration, activating photosensitizers to induce collagen crosslinking and wound sealing. The conformal patch maintains optical performance even under movement, enabling continuous phototherapy during daily life activity. Remarkably, after PTB-driven sealing, wound healing is accelerated in both linear and circular wounds, mediated by PBM-induced tissue regeneration. A further clinical study on normal human facial skins demonstrates that a single PBM treatment with the patch acutely improves viscoelastic recovery and attenuates superficial erythema. This ambient light-activatable biophotonic patch platform would pave a big avenue toward PTB, PBM, and various biomedical applications.