Pulsed-dye laser therapy for successful management of refractory neurogenic rosacea.

Neurogenic rosacea (NR) poses a therapeutic challenge due to its resistance to conventional treatments. This study explores the efficacy of pulsed-dye laser (PDL) therapy in managing NR. We present two cases of NR with severe facial discomfort and photoaging, treated with PDL alongside oral medications. Remarkably, PDL significantly alleviated pain and improved skin appearance in both cases, with sustained relief for over 2 years. Mechanistically, PDL may modulate neuropeptides and nerve fiber density implicated in NR pathogenesis. Our findings suggest PDL as a promising therapeutic avenue for NR, warranting further investigation and consideration in clinical practice.