[Abdominal Pain as the First Manifestation of Rare Hematological Diseases: A Case Series].

Abdominal pain frequently poses a significant diagnostic challenge because of its myriad etiologies. In this case series, we describe four patients initially presenting with abdominal pain who were subsequently diagnosed with rare hematological disorders: namely, paroxysmal nocturnal hemoglobinuria (PNH), myeloproliferative neoplasm (MPN), sickle cell Disease (SCD), and aggressive systemic mastocytosis (ASM). We discuss the unique pathophysiological mechanisms underlying the abdominal pain in these cases and emphasize the importance of considering hematological disorders in the differential diagnosis of abdominal pain.