World journal of nephrology · 2026
Protective effect of boric acid on kidney tissue and oxidative stress after testicular torsion/detorsion in male rats.
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Adam Uğur M, Alkan Metin, Sezen Şaban C, Kavutçu Mustafa, Arslan Mustafa
Аннотация
BACKGROUND: Testicular ischemia/reperfusion (I/R) injury may affect distant organs. During I/R, metabolites formed in the affected organ are released into the circulation; thus, non-ischemic organs, such as the kidneys and lungs, become involved in the inflammatory process, even if they are not primarily affected. Damage from testicular torsion/detorsion (T/D) models has been shown to affect kidneys. There is a need to examine the nephroprotective effect of boric acid (BA), which is known to have antioxidant effects, on kidney damage.
AIM: To investigate kidney damage in a rat testicular T/D model and the effectiveness of BA on this distant organ damage.
METHODS: Twenty-four male Wistar albino rats were divided into four groups (n = 6 each)-control (group C), BA (group BA), T/D (group I/R), BA-T/D (group BA-I/R). In all groups, the scrotum was cut longitudinally, and the testis was dissected. No medication was administered to groups C and group I/R. Groups BA and group BA-I/R were administered 50 mg/kg BA intraperitoneally half an hour before the surgical procedure. The testicular T/D model was applied to groups I/R and group BA-I/R. The malondialdehyde (MDA) level, catalase, glutathione S-transferase, and paraoxonase-1 (PON-1) enzyme activities were measured in kidney tissue. Additionally, sections were taken and evaluated for histopathological examination.
RESULTS: An increase in MDA levels and a decrease in PON-1 activity were detected in the I/R group compared to the control group (P = 0.001, P = 0.002, respectively). MDA levels were found to be significantly lower in the BA-I/R group than in the I/R group (P = 0.041). PON-1 enzyme activity was found to be significantly higher in the BA-I/R group than in the I/R group (P = 0.048). The light microscopy examination showed an increase in glomerular vacuolization, tubular dilatation, vascular vacuolization and hypertrophy (VVH), and tubular cell degeneration and necrosis damage scores in the I/R group compared to the control group (P = 0.003, P = 0.005, P = 0.008, and P < 0.001, respectively). In the I/R group treated with BA, tubular dilatation and VVH scores decreased compared to the I/R group (P = 0.037 and P = 0.048, respectively).
CONCLUSION: These findings show that the testicular T/D model in rats causes kidney damage, and BA administration reduces this damage in the kidneys.
AIM: To investigate kidney damage in a rat testicular T/D model and the effectiveness of BA on this distant organ damage.
METHODS: Twenty-four male Wistar albino rats were divided into four groups (n = 6 each)-control (group C), BA (group BA), T/D (group I/R), BA-T/D (group BA-I/R). In all groups, the scrotum was cut longitudinally, and the testis was dissected. No medication was administered to groups C and group I/R. Groups BA and group BA-I/R were administered 50 mg/kg BA intraperitoneally half an hour before the surgical procedure. The testicular T/D model was applied to groups I/R and group BA-I/R. The malondialdehyde (MDA) level, catalase, glutathione S-transferase, and paraoxonase-1 (PON-1) enzyme activities were measured in kidney tissue. Additionally, sections were taken and evaluated for histopathological examination.
RESULTS: An increase in MDA levels and a decrease in PON-1 activity were detected in the I/R group compared to the control group (P = 0.001, P = 0.002, respectively). MDA levels were found to be significantly lower in the BA-I/R group than in the I/R group (P = 0.041). PON-1 enzyme activity was found to be significantly higher in the BA-I/R group than in the I/R group (P = 0.048). The light microscopy examination showed an increase in glomerular vacuolization, tubular dilatation, vascular vacuolization and hypertrophy (VVH), and tubular cell degeneration and necrosis damage scores in the I/R group compared to the control group (P = 0.003, P = 0.005, P = 0.008, and P < 0.001, respectively). In the I/R group treated with BA, tubular dilatation and VVH scores decreased compared to the I/R group (P = 0.037 and P = 0.048, respectively).
CONCLUSION: These findings show that the testicular T/D model in rats causes kidney damage, and BA administration reduces this damage in the kidneys.