Privacy-Preserving Hybrid GA-LSTM Ensemble for Typhoid Detection Using Optimised Clinical Feature Selection.

Background/Objectives: Typhoid fever remains a major public health challenge in many low-income countries, where overlapping clinical symptoms and the limited reliability of conventional diagnostic procedures hinder accurate diagnosis. This study aims to develop a reliable and efficient diagnostic framework that automates typhoid fever detection from clinical data while preserving patient privacy. Methods: To achieve this objective, we propose a hybrid framework combining genetic algorithm (GA)-based feature selection, a Convolutional Neural Network-Long Short-Term Memory (CNN-LSTM) deep learning classifier, and federated learning. The GA identifies the most informative clinical features, reducing redundancy and computational complexity. The selected features are then used to train a CNN-LSTM model in a federated learning setup using the Federated Averaging (FedAvg) algorithm, enabling collaborative model training across multiple clients without sharing raw patient data. Results: Experimental results show that the proposed framework achieves 92% accuracy, with a strong F1-score and satisfactory sensitivity. Compared to models trained on the full feature set, the proposed approach requires less memory and shorter training time, while maintaining balanced performance under class imbalance. Conclusions: These results demonstrate that integrating evolutionary feature selection, deep sequential learning, and federated training provides an effective and privacy-aware solution for multi-class typhoid fever diagnosis. The proposed framework is particularly suitable for clinical environments with limited data access and constrained resources.