[The advances in biological therapy in chronic rhinosinusitis with nasal polyps].

Objective

Chronic rhinosinusitis with nasal polyps（CRSwNP） is a highly heterogeneous chronic inflammatory disorder of the nasal and paranasal sinus mucosa. Despite adequate medical therapy and/or endoscopic sinus surgery, a substantial proportion of patients continue to experience persistent symptoms and frequent recurrence. In recent years, with advances in the understanding of the pathophysiological mechanisms of CRSwNP, biologics have emerged as a novel therapeutic option for patients with refractory CRSwNP. A review of the literature was performed to summarize the recent advances in biological therapies for the treatment of CRSwNP.