Open veterinary journal · 2026
Assessing the effects of linseed consumption on thyroid hormones and hepatic toxicity in rats drenched with Cordarone overdose.
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Ubaid Moayad Mijbil, Abed Sara Najem, Jabbar Shaimaa, Oraibi Hadiya Jumaah, Kadhim Shatha Hussein
Аннотация
BACKGROUND: Cordarone, a benzofuranic-derivative iodine-rich medication primarily used for tachyarrhythmias, frequently induces alterations in the peripheral metabolism of thyroid hormones, predominantly by inhibiting 5'-deiodinase activity, resulting in elevated serum thyroxine and reverse triiodothyronine (T3) levels, alongside diminished serum T3 concentrations. Overt thyroid dysfunction, which manifests as either Cordarone-induced thyrotoxicosis. Linseed oil or flaxseed oil is a type of oil that comes from seeds. It is one of the oldest oils on the market. Solvent-processed flaxseed oil has been used as a drying oil in painting and varnishing for hundreds of years. Raw oil is utilized as an astringent in fungicidal lotion. It also acts as an insecticide and has some insect-repelling effects.
AIM: The study sought to show the therapeutic effects of linseed oil on biochemical parameters in rats against the toxic effects of Cordarone.
METHODS: In this study, we used twenty-four adult male rats and splited into three groups: control group: drenched standard nutrition only. Cordarone group: drenched Cordarone (100 mg/kg/day) orally by gavage. Cordarone + Linseed oil group: rats were drenched with Cordarone (100 mg/kg/day) and linseed oil (3 ml/kg/day) for a month. At the end of this experiment, the rats were scarified and blood samples were taken from the animals for biochemical parameters (ALT, AST, troponin, TSH, T3, and T4).
RESULTS: The data showed the positive effect of linseed in improving the thyroid gland, heart, and liver against the toxic effect of Cordarone.
CONCLUSION: Linseed had a positive effect against the toxic effects of Cordarone by enhancing hematology parameters. These findings proved benefit of linseed.
AIM: The study sought to show the therapeutic effects of linseed oil on biochemical parameters in rats against the toxic effects of Cordarone.
METHODS: In this study, we used twenty-four adult male rats and splited into three groups: control group: drenched standard nutrition only. Cordarone group: drenched Cordarone (100 mg/kg/day) orally by gavage. Cordarone + Linseed oil group: rats were drenched with Cordarone (100 mg/kg/day) and linseed oil (3 ml/kg/day) for a month. At the end of this experiment, the rats were scarified and blood samples were taken from the animals for biochemical parameters (ALT, AST, troponin, TSH, T3, and T4).
RESULTS: The data showed the positive effect of linseed in improving the thyroid gland, heart, and liver against the toxic effect of Cordarone.
CONCLUSION: Linseed had a positive effect against the toxic effects of Cordarone by enhancing hematology parameters. These findings proved benefit of linseed.