Assessing the effects of linseed consumption on thyroid hormones and hepatic toxicity in rats drenched with Cordarone overdose.

BACKGROUND

Cordarone, a benzofuranic-derivative iodine-rich medication primarily used for tachyarrhythmias, frequently induces alterations in the peripheral metabolism of thyroid hormones, predominantly by inhibiting 5'-deiodinase activity, resulting in elevated serum thyroxine and reverse triiodothyronine (T3) levels, alongside diminished serum T3 concentrations. Overt thyroid dysfunction, which manifests as either Cordarone-induced thyrotoxicosis. Linseed oil or flaxseed oil is a type of oil that comes from seeds. It is one of the oldest oils on the market. Solvent-processed flaxseed oil has been used as a drying oil in painting and varnishing for hundreds of years. Raw oil is utilized as an astringent in fungicidal lotion. It also acts as an insecticide and has some insect-repelling effects.

AIM: The study sought to show the therapeutic effects of linseed oil on biochemical parameters in rats against the toxic effects of Cordarone.

METHODS

In this study, we used twenty-four adult male rats and splited into three groups: control group: drenched standard nutrition only. Cordarone group: drenched Cordarone (100 mg/kg/day) orally by gavage. Cordarone + Linseed oil group: rats were drenched with Cordarone (100 mg/kg/day) and linseed oil (3 ml/kg/day) for a month. At the end of this experiment, the rats were scarified and blood samples were taken from the animals for biochemical parameters (ALT, AST, troponin, TSH, T3, and T4).

RESULTS

The data showed the positive effect of linseed in improving the thyroid gland, heart, and liver against the toxic effect of Cordarone.

CONCLUSION

Linseed had a positive effect against the toxic effects of Cordarone by enhancing hematology parameters. These findings proved benefit of linseed.