Strategies for the control of Cryptosporidium parvum infection in calves.

Cryptosporidium parvum is a protozoan parasite that is now recognized as one of the leading causes of diarrhea in young calves. To date, there are no drugs or preventive measures available for the control of this disease. We have developed an oral vaccine that, when given to calves at birth, protects against experimental challenge with C. parvum. However, when field tested on a large dairy operation with heavy endemic C. parvum infection, the vaccine failed to provide protection. The difference in these results is most likely due to uncontrolled early (probably within hours of birth) exposure to C. parvum on the farm versus controlled exposure at 1 wk of age in the experimental trials. The successful control of C. parvum in the field may require vaccines that generate a rapid (within the first few days of life) cell-mediated immune response in the calf. Successful use of such a vaccine will also require improved hygiene and management practices to minimize the exposure of calves to C. parvum in the initial days of life, thus allowing time for protective immune responses to be generated. Careful attention to hygiene in the management of sick calves is also critical to minimize the spread of the parasite to other animals.