Annals of medicine and surgery (2012) · 2026
Tripe palm with acanthosis nigricans in a patient with gastric adenocarcinoma: a rare case report.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Budha Bishal, Pandey Pujan, Dabadi Sneha, Kc Tej Bahadur, Poudel Bishal, Mainali Atul, Kharel Roshani, Chaudhary Roshan, Pandit Rabin
Аннотация
INTRODUCTION AND IMPORTANCE: Tripe palms (TP) and acanthosis nigricans (AN) are rare paraneoplastic dermatoses strongly associated with underlying malignancies, particularly gastric and lung carcinoma. Here, we report a case highlighting this uncommon dermatological manifestation as a marker of gastric carcinoma.
CASE PRESENTATION: We report a case of 47-year-old man who presented with progressive hyperpigmented, hyperkeratotic cutaneous lesions consistent with TP and AN. Further evaluation revealed gastric adenocarcinoma with nodal metastasis, confirmed by histopathology and positron emission tomography - computed tomography. Following neoadjuvant chemotherapy and partial gastrectomy, he demonstrated both clinical and marked regression of cutaneous manifestations.
DISCUSSION: TP and AN may serve as early paraneoplastic markers.
CONCLUSION: Early recognition of paraneoplastic cutaneous manifestation can provide an early clue to internal malignancy, warranting prompt evaluation and timely treatment for better outcomes.
CASE PRESENTATION: We report a case of 47-year-old man who presented with progressive hyperpigmented, hyperkeratotic cutaneous lesions consistent with TP and AN. Further evaluation revealed gastric adenocarcinoma with nodal metastasis, confirmed by histopathology and positron emission tomography - computed tomography. Following neoadjuvant chemotherapy and partial gastrectomy, he demonstrated both clinical and marked regression of cutaneous manifestations.
DISCUSSION: TP and AN may serve as early paraneoplastic markers.
CONCLUSION: Early recognition of paraneoplastic cutaneous manifestation can provide an early clue to internal malignancy, warranting prompt evaluation and timely treatment for better outcomes.