The British journal of ophthalmology · 2026
Monitoring tear monocyte chemoattractant protein-1 levels after endonasal versus external dacryocystorhinostomy: a prospective, longitudinal study.
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Karabulut Sinem, Saruhan Ercan, Karabulut Müjdat, Akmaz Okan
Аннотация
BACKGROUND: We aimed to monitor changes in tear monocyte chemotactic protein-1 (MCP-1) levels following endonasal dacryocystorhinostomy (endo-DCR) and external dacryocystorhinostomy (ext-DCR).
METHODS AND ANALYSIS: This study was designed as a prospective, longitudinal study and included 42 eyes in the endo-DCR group and 48 eyes in the ext-DCR group. We monitored changes in tear MCP-1 levels. Tear samples were collected on the day before surgery, the first week, and the first and sixth months after surgery to compare changes in tear MCP-1 levels between and within groups. Surgery time and success rates were also compared.
RESULTS: The mean MCP-1 levels at baseline, first and sixth months were similar between the groups (p=0.722, p=0.661, p=0.676, respectively). In the first week, it was significantly higher in the ext-DCR group than in the endo-DCR group (p<0.001). In the endo-DCR group, it showed a significant and continuous decrease until the first month (p<0.001), and the decrease stabilised in the sixth month. In the ext-DCR group, the mean MCP-1 level displayed a significant peak increase during the first week, followed by a steady decline until the sixth month (p<0.001). The surgery time was longer in the ext-DCR group (p<0.001) and showed a significant correlation with MCP-1 levels in the first week (Spearman's rho=0.857, p <0.001). The groups' subjective and anatomical success rates were similar (p=0.642, p=0.549, respectively).
CONCLUSION: Both surgeries demonstrated comparable success rates and decreased tear MCP-1 levels during follow-up. In the first week, the mean MCP-1 level exhibited a significant peak increase in the ext-DCR group. Extended surgical duration is a recognised factor affecting the wound-healing process.
METHODS AND ANALYSIS: This study was designed as a prospective, longitudinal study and included 42 eyes in the endo-DCR group and 48 eyes in the ext-DCR group. We monitored changes in tear MCP-1 levels. Tear samples were collected on the day before surgery, the first week, and the first and sixth months after surgery to compare changes in tear MCP-1 levels between and within groups. Surgery time and success rates were also compared.
RESULTS: The mean MCP-1 levels at baseline, first and sixth months were similar between the groups (p=0.722, p=0.661, p=0.676, respectively). In the first week, it was significantly higher in the ext-DCR group than in the endo-DCR group (p<0.001). In the endo-DCR group, it showed a significant and continuous decrease until the first month (p<0.001), and the decrease stabilised in the sixth month. In the ext-DCR group, the mean MCP-1 level displayed a significant peak increase during the first week, followed by a steady decline until the sixth month (p<0.001). The surgery time was longer in the ext-DCR group (p<0.001) and showed a significant correlation with MCP-1 levels in the first week (Spearman's rho=0.857, p <0.001). The groups' subjective and anatomical success rates were similar (p=0.642, p=0.549, respectively).
CONCLUSION: Both surgeries demonstrated comparable success rates and decreased tear MCP-1 levels during follow-up. In the first week, the mean MCP-1 level exhibited a significant peak increase in the ext-DCR group. Extended surgical duration is a recognised factor affecting the wound-healing process.