Cell · 2026
Identification of the tendon/ligament stem cell in mice and humans.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Hu Lingling, Sun Jun, Morse Kyle W, Bok Seoyeon, Zheng Yimin, Chan Un In, Choi Han, Macfarlane Eugenie, Yallowitz Alisha R, Cung Michelle, Cong Ting, Carpen Peyton Lee, La Manna Federico, Debnath Shawon, Li Haiyin, Xu Tim, Wang Lipeng, Zheng Yangkang, Hirose Takeshi, Serio Ryan N, Lu Billy, Chaffee Ryan J, Scheben Armin, Zheng Ling J, McCormick Jason, Shinn Daniel, Pajak Anthony, Araghi Kasra, Zhao Eric, Yemelyanova Anna, Cao Chike, Pitt Geoffrey S, Rodeo Scott A, Nowak Dawid G, Iyer Sravisht, Greenblatt Matthew B
Аннотация
Ligamentum flavum (LF) hypertrophy resulting in spinal cord compression is a key cause of lumbar spinal stenosis (LSS). There are no medical therapies for LSS, in part because the identity of the tendon/ligament stem cell (TLSC) mediating LSS remains unclear. Here, we identify the TLSC present in all tendons and ligaments in humans and mice as Lin-Thy1.2-Sca-1-CD73+CD140α- cells that display self-renewal and give rise to all other tenocyte lineage cells. This TLSC also sits at the apex of their differentiation hierarchy, as determined by in vivo somatic-variant-based lineage tracing. LSS induction led to druggable, calcium signaling-dependent, cell-intrinsic reprogramming of the TLSCs to increase their tenocyte output. Overall, this work identifies the TLSC and establishes dysregulated differentiation of this cell as a mechanism contributing to LSS. This TLSC is anticipated to play a central role in other disorders of tendons and ligaments.