Asian Pacific journal of cancer prevention : APJCP · 2026
Long-Term Quality-of-Life Outcomes After Endoscopic Resection of Sinonasal and Skull Base Tumours: A Systematic Review and Meta-Analysis.
СтатьяСистематический обзорМетаанализНазвание и аннотация: Перевод в очереди
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Lecoq Anne-Lise, Stratakis Constantine A, Viengchareun Say, Chaligné Ronan, Tosca Lucie, Deméocq Vianney, Hage Mirella, Berthon Annabel, Faucz Fabio R, Hanna Patrick, Boyer Hadrien-Gaël, Servant Nicolas, Salenave Sylvie, Tachdjian Gérard, Adam Clovis, Benhamo Vanessa, Clauser Eric, Guiochon-Mantel Anne, Young Jacques, Lombès Marc, Bourdeau Isabelle, Maiter Dominique, Tabarin Antoine, Bertherat Jérôme, Lefebvre Hervé, de Herder Wouter, Louiset Estelle, Lacroix André, Chanson Philippe, Bouligand Jérôme, Kamenický Peter
Аннотация
INTRODUCTION: The present meta-analysis and systematic review aims to address the gap by examining long-term quality-of-life outcomes following endoscopic resection of sinonasal and skull base tumours. Materials and procedures: We searched databases such as PubMed, Scopus, Embase, and Google Scholar for research publications published between 2005 and 2024, following the PRISMA guidelines. R software was used to perform the meta-analysis, and Cochrane's ROB 2.0 tool was employed to assess the risk of bias in the included studies. The I² statistic was used to evaluate heterogeneity. A funnel plot, along with Egger's regression test, was used to assess publication bias.
RESULTS: The meta-analysis showed that quality of life (QOL) typically declined shortly after surgery, with a statistically significant worsening indicated by the SNOT-22 score (standardized mean difference [SMD] 0.49; 95% CI: 0.01 to 0.96) and a non-significant change on the ASBQ score (SMD -2.72; 95% CI: -10.93 to 5.49). However, results from the SNOT-20 score suggested a non-significant immediate improvement (SMD -4.70; 95% CI: -23.95 to 14.55). In the long term, patients experienced a clear and statistically significant overall improvement in QOL (p < 0.01), reflected by reductions in SNOT-22 (SMD -0.23; 95% CI: -0.61 to 0.14) and SNOT-20 scores (SMD -5.46; 95% CI: -26.93 to 16.02), alongside an increase in ASBQ scores (SMD 0.77; 95% CI: -2.18 to 3.71).
CONCLUSION: Endoscopic resection of sinonasal and skull base tumours significantly improves postoperative sinonasal quality-of-life (QOL) symptoms. Although symptoms may temporarily worsen during the perioperative period, most patients generally return to baseline QOL in the long term.
RESULTS: The meta-analysis showed that quality of life (QOL) typically declined shortly after surgery, with a statistically significant worsening indicated by the SNOT-22 score (standardized mean difference [SMD] 0.49; 95% CI: 0.01 to 0.96) and a non-significant change on the ASBQ score (SMD -2.72; 95% CI: -10.93 to 5.49). However, results from the SNOT-20 score suggested a non-significant immediate improvement (SMD -4.70; 95% CI: -23.95 to 14.55). In the long term, patients experienced a clear and statistically significant overall improvement in QOL (p < 0.01), reflected by reductions in SNOT-22 (SMD -0.23; 95% CI: -0.61 to 0.14) and SNOT-20 scores (SMD -5.46; 95% CI: -26.93 to 16.02), alongside an increase in ASBQ scores (SMD 0.77; 95% CI: -2.18 to 3.71).
CONCLUSION: Endoscopic resection of sinonasal and skull base tumours significantly improves postoperative sinonasal quality-of-life (QOL) symptoms. Although symptoms may temporarily worsen during the perioperative period, most patients generally return to baseline QOL in the long term.