Hepatology communications · 2026
Timing and trajectory of acute kidney injury predict mortality in alcohol-associated hepatitis: A multinational cohort study.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Fakhoury Butros, Khan Ali, Danpanichkul Pojsakorn, Albhaisi Omar, Soni Kriti, Parraga Ximena, Idalsoaga Francisco, Valsan Arun, Nair Gowripriya, Arnold Jorge, Ayala-Valverde María, Ramirez-Cadiz Carolina, Roblero Juan Pablo, Simian Daniela, Velasco José Antonio Velarde-Ruiz, Córdova Jacqueline, Mendizabal Manuel, Marciano Sebastián, Chacko Kristina R, Skladaný Lubomir, Kukla Michał, Sanyal Arun J, Shah Vijay H, Kamath Patrick S, Arrese Marco, Dunn Winston, Singal Ashwani K, Bataller Ramon, Díaz Luis Antonio, Arab Juan Pablo
Аннотация
BACKGROUND: Acute kidney injury (AKI) is common in alcohol-associated hepatitis (AH) and associated with poor outcomes, yet the prognostic implications of AKI timing and early renal trajectory remain unclear.
METHODS: In this prospective multicenter cohort from the Global AlcHep Prospective Database, patients with AH were classified as no AKI, prevalent AKI at admission, or incident AKI during hospitalization. The primary outcome was 90-day mortality, using competing-risks regression with liver transplantation as the competing event. A 7-day landmark analysis assessed the prognostic impact of AKI trajectory among prevalent AKI patients.
RESULTS: Among 581 patients, 37% had prevalent AKI, and 11% developed incident AKI. The 90-day mortality was 18.2% (11 transplantations, 1.9%). Prevalent AKI was predominantly functional (84%), while incident AKI had a higher proportion of structural injury (44%). Despite lower baseline severity [median mDF 59.8 vs. 69.3 and lower rates of ACLF grade 3 (23.4% vs. 45.3%)], incident AKI conferred mortality of similar magnitude to prevalent AKI (sHR 2.18, 95% CI 1.19-3.99 vs. sHR 1.80, 95% CI 1.02-3.16). Among 7-day survivors (N=457), prevalent AKI without progression had mortality similar to no AKI (sHR 1.27, p=0.52), while prevalent AKI with progression carried the worst prognosis (sHR 3.34, 95% CI 1.44-7.77).
CONCLUSION: Both prevalent and incident AKI independently predict mortality in AH. Incident AKI confers equivalent risk despite lower disease severity and a distinct etiologic profile with higher rates of intrinsic renal injury. Early renal trajectory refines risk beyond baseline AKI status, where absence of progression approximates outcomes of those without AKI, while progressive AKI identifies the highest-risk subgroup.
METHODS: In this prospective multicenter cohort from the Global AlcHep Prospective Database, patients with AH were classified as no AKI, prevalent AKI at admission, or incident AKI during hospitalization. The primary outcome was 90-day mortality, using competing-risks regression with liver transplantation as the competing event. A 7-day landmark analysis assessed the prognostic impact of AKI trajectory among prevalent AKI patients.
RESULTS: Among 581 patients, 37% had prevalent AKI, and 11% developed incident AKI. The 90-day mortality was 18.2% (11 transplantations, 1.9%). Prevalent AKI was predominantly functional (84%), while incident AKI had a higher proportion of structural injury (44%). Despite lower baseline severity [median mDF 59.8 vs. 69.3 and lower rates of ACLF grade 3 (23.4% vs. 45.3%)], incident AKI conferred mortality of similar magnitude to prevalent AKI (sHR 2.18, 95% CI 1.19-3.99 vs. sHR 1.80, 95% CI 1.02-3.16). Among 7-day survivors (N=457), prevalent AKI without progression had mortality similar to no AKI (sHR 1.27, p=0.52), while prevalent AKI with progression carried the worst prognosis (sHR 3.34, 95% CI 1.44-7.77).
CONCLUSION: Both prevalent and incident AKI independently predict mortality in AH. Incident AKI confers equivalent risk despite lower disease severity and a distinct etiologic profile with higher rates of intrinsic renal injury. Early renal trajectory refines risk beyond baseline AKI status, where absence of progression approximates outcomes of those without AKI, while progressive AKI identifies the highest-risk subgroup.