Clinical and experimental dermatology · 2026
Association between palisaded and interstitial granulomatous dermatoses and haematological neoplasms: evidence beyond coincidence?
СтатьяСистематический обзорНазвание и аннотация: Перевод в очереди
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Hamani Syna, Séverac François, Cribier Bernard, Lipsker Dan, Lenormand Cédric
Аннотация
BACKGROUND: Palisaded and interstitial granulomatous dermatoses (PIGDs) are a spectrum of presumed reactive cutaneous disorders sometimes associated with underlying diseases, notably malignant haemopathies. Specific associations between some of these dermatoses and particular haematological neoplasms may exist.
OBJECTIVES: To describe the spectrum of haematological neoplasms associated with PIGDs and to establish whether specific associations exist.
METHODS: We conducted a retrospective monocentric study of all cases of patients with PIGD associated with haematological neoplasms seen in our department and undertook a systematic literature review. Clinical and pathological data were extracted from patient files and articles.
RESULTS: In total, 146 cases were identified (31 from our institution, 115 from the literature review). Granuloma annulare (N = 76) and elastolytic giant cell granulomas (N = 9) were mainly associated with B- and T-cell lymphoid neoplasms (59/85, 69%). Four patients with necrobiosis lipoidica were identified, of which two were associated with plasma cell dyscrasias. Interstitial granulomatous dermatitis (N = 22) was associated in half of patients with myeloid neoplasms (n = 11). This association was even stronger (n = 11, 65%) for palisaded neutrophilic granulomatous dermatitis (N = 17), especially with chronic myelomonocytic leukaemia (n = 8, 47%). We also identified 18 patients with unclassified granulomatous dermatoses that were most often associated with lymphoid neoplasm (n = 10, 56%). Medical history and clinical course data suggestive of a link that was not coincidental were identified in 41 of 146 patients (28.1%).
CONCLUSIONS: This work shows that some PIGD appear to be specifically associated with certain types of haematological neoplasms. The pathophysiological basis of these associations remains to be elucidated.
OBJECTIVES: To describe the spectrum of haematological neoplasms associated with PIGDs and to establish whether specific associations exist.
METHODS: We conducted a retrospective monocentric study of all cases of patients with PIGD associated with haematological neoplasms seen in our department and undertook a systematic literature review. Clinical and pathological data were extracted from patient files and articles.
RESULTS: In total, 146 cases were identified (31 from our institution, 115 from the literature review). Granuloma annulare (N = 76) and elastolytic giant cell granulomas (N = 9) were mainly associated with B- and T-cell lymphoid neoplasms (59/85, 69%). Four patients with necrobiosis lipoidica were identified, of which two were associated with plasma cell dyscrasias. Interstitial granulomatous dermatitis (N = 22) was associated in half of patients with myeloid neoplasms (n = 11). This association was even stronger (n = 11, 65%) for palisaded neutrophilic granulomatous dermatitis (N = 17), especially with chronic myelomonocytic leukaemia (n = 8, 47%). We also identified 18 patients with unclassified granulomatous dermatoses that were most often associated with lymphoid neoplasm (n = 10, 56%). Medical history and clinical course data suggestive of a link that was not coincidental were identified in 41 of 146 patients (28.1%).
CONCLUSIONS: This work shows that some PIGD appear to be specifically associated with certain types of haematological neoplasms. The pathophysiological basis of these associations remains to be elucidated.