PLoS pathogens · 2019
Dietary zinc and the control of Streptococcus pneumoniae infection.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Eijkelkamp Bart A, Morey Jacqueline R, Neville Stephanie L, Tan Aimee, Pederick Victoria G, Cole Nerida, Singh Prashina P, Ong Cheryl-Lynn Y, Gonzalez de Vega Raquel, Clases David, Cunningham Bliss A, Hughes Catherine E, Comerford Iain, Brazel Erin B, Whittall Jonathan J, Plumptre Charles D, McColl Shaun R, Paton James C, McEwan Alastair G, Doble Philip A, McDevitt Christopher A
Аннотация
Human zinc deficiency increases susceptibility to bacterial infection. Although zinc supplementation therapies can reduce the impact of disease, the molecular basis for protection remains unclear. Streptococcus pneumoniae is a major cause of bacterial pneumonia, which is prevalent in regions of zinc deficiency. We report that dietary zinc levels dictate the outcome of S. pneumoniae infection in a murine model. Dietary zinc restriction impacts murine tissue zinc levels with distribution post-infection altered, and S. pneumoniae virulence and infection enhanced. Although the activation and infiltration of murine phagocytic cells was not affected by zinc restriction, their efficacy of bacterial control was compromised. S. pneumoniae was shown to be highly sensitive to zinc intoxication, with this process impaired in zinc restricted mice and isolated phagocytic cells. Collectively, these data show how dietary zinc deficiency increases sensitivity to S. pneumoniae infection while revealing a role for zinc as a component of host antimicrobial defences.